Počet záznamů: 1
Expression of gamma-tubulin in non-small cell lung cancer and effect on patient survival
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SYSNO ASEP 0505232 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Expression of gamma-tubulin in non-small cell lung cancer and effect on patient survival Tvůrce(i) Maounis, N.F. (US)
Dráberová, Eduarda (UMG-J) RID, ORCID
Trakas, N. (GR)
Chorti, M. (GR)
Riga, D. (GR)
Tzannis, K. (GR)
Kanakis, M. (GR)
Voralu, K. (US)
Ellina, E. (GR)
Mahera, E. (GR)
Demonakou, M. (GR)
Lioulias, A. (GR)
Dráber, Pavel (UMG-J) RID, ORCID
Katsetos, C.D. (US)Celkový počet autorů 14 Zdroj.dok. Histology and Histopathology. - : Universidad de Murcia - ISSN 0213-3911
Roč. 34, č. 1 (2019), s. 81-90Poč.str. 10 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. ES - Španělsko Klíč. slova Gamma-tubulin ; Immunohistochemistry ; Non-small cell lung cancer ; Survival Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Oncology CEP LTAUSA17052 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA17-11898S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UMG-J - RVO:68378050 UT WOS 000452158000008 DOI 10.14670/HH-18-027 Anotace Introduction. It has been reported that overexpression and altered compartmentalization of gamma-tubulin may contribute to tumorigenesis and tumor aggressiveness in a variety of human malignancies. We have shown that gamma-tubulin expression and cellular distribution pattern is also altered in non-small cell lung cancer (NSCLC) (Histol. Histopathol. 2012, 27: 11831194). In the present study we examined the relationship between gamma-tubulin expression and patient overall survival (OS). Material and methods. Immunohistochemistry was performed, with well-characterized anti-gamma-tubulin antibodies, on 109 formalin-fixed, paraffin-embedded NSCLC specimens (p-TNM stage I-III). gamma-Tubulin labeling indexes (LIs) were determined, and the association of gamma-tubulin expression with clinicopathological parameters was evaluated. To analyze OS rates according to gamma-tubulin LIs, patients were categorized into three groups: those with low (0-30%), intermediate (31-69%) or high (70-100%) gamma-tubulin LI. Association of clinicopathological parameters and gamma-tubulin with survival were examined using univariate and multivariate Cox regression analysis. Results. No statistically significant association was seen between gamma-tubulin overexpression and histological type, tumor differentiation, p-TNM stage and adenocarcinoma subtyping. Longer survival was observed in the high gamma-tubulin LI group of patients with p-TNM stages II+III when compared to intermediate or low gamma-tubulin LI groups, but the difference was not statistically significant (p=0.066). On the other hand, when combined low and intermediate gamma-tubulin LI groups (p-TNM stages II+III) where compared to high gamma-tubulin LI group, statistically significant longer survival was observed in high gamma-tubulin group (p=0.021). Conclusion. Our findings suggest that level of gamma-tubulin expression may have an impact on patient survival at more advanced NSCLC stages. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2020 Elektronická adresa https://www.hh.um.es/Abstracts/Vol_34/34_1/34_1_81.htm
Počet záznamů: 1