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Assessment of agonistic and antagonistic properties of widely used oral care antimicrobial substances toward steroid estrogenic and androgenic receptors
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SYSNO ASEP 0504291 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Assessment of agonistic and antagonistic properties of widely used oral care antimicrobial substances toward steroid estrogenic and androgenic receptors Tvůrce(i) Michalíková, Klára (MBU-M) ORCID
Linhartová, Lucie (MBU-M) RID, ORCID
Ezechiáš, Martin (MBU-M) RID
Cajthaml, Tomáš (MBU-M) RID, ORCIDZdroj.dok. Chemosphere. - : Elsevier - ISSN 0045-6535
Roč. 217, FEB 2019 (2019), s. 534-541Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova T47D-CXCL12 ; Endocrine disruptive compounds ; Mouthwash Vědní obor RIV FR - Farmakologie a lékárnická chemie Obor OECD Toxicology CEP GJ17-15678Y GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora MBU-M - RVO:61388971 UT WOS 000456223500058 EID SCOPUS 85057193460 DOI 10.1016/j.chemosphere.2018.11.006 Anotace Personal care product consumption has increased in the last decades. A typical representative ingredient, i.e., triclosan, was identified in the scientific literature as an endocrine disruptor, and its use is restricted in several applications. Oral hygiene formulations contain various compounds, including synthetic phenol derivatives, quaternary ammonium compounds (QAC5), various amides and amines, or natural essential oils containing terpenes. The aim of this paper was to explore possible endocrine-disrupting effects of these most-used compounds. For this purpose, two different assays based on recombinant yeast (BMAEREluc/ER alpha, BMAEREIuc/AR) and human cell lines (T47D, AIZ-AR) were employed to investigate the agonistic and antagonistic properties of these compounds on human estrogen and androgen receptors. The results showed that none of the compounds were indicated as agonists of the steroid receptors. However, octenidine (00', QAC-like) and hexadecylpyridinium (HOP, QAC) were able to completely inhibit both androgenic (IC50 OCT = 0.84 mu M, IC50 HDP = 1.66 mu M) and estrogenic (IC50 OCT = 0.50 mu M, IC50 HDP = 1.64 mu M) signaling pathways in a dose-dependent manner. Additionally, chlorhexidine was found to inhibit the 17 beta-estradiol response, with a similar IC50 (2.9 mu M). In contrast, the natural terpenes thymol and menthol were found to be competitive antagonists of the receptors, however, their IC50 values were higher (by orders of magnitude). We tried to estimate the risk associated with the presence of these compounds in environmental matrices by calculating hazard quotients (HQs), and the calculated HQs were found to be close to or greater than 1 only when predicted environmental concentrations were used for surface waters. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2020 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0045653518321039?via%3Dihub
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