Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases

de la Fuente, J.; Antunes, S.; Bonnet, S.; Cabezas Cruz, Alejandro; Domingos, A.G.; Estrada-Peňa, A.; Johnson, N.; Kocan, K.M.; Mansfield, K. L.; Nijhof, A.M.; Papa, A.; Rudenko, Natalia; Villar, M.; Alberdi, P.; Torina, A.; Ayllón, N.; Vancová, Marie; Golovchenko, Maryna; Grubhoffer, Libor; Caracappa, S.; Fooks, A. R.; Gortazar, C.; Rego, Ryan O. M.

doi:https://dx.doi.org/10.3389/fcimb.2017.00114

Počet záznamů: 1

Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases

1.

SYSNO ASEP	0479057
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases
Tvůrce(i)	de la Fuente, J. (ES) Antunes, S. (PT) Bonnet, S. (FR) Cabezas Cruz, Alejandro (BC-A) Domingos, A.G. (PT) Estrada-Peňa, A. (ES) Johnson, N. (GB) Kocan, K.M. (US) Mansfield, K. L. (GB) Nijhof, A.M. (DE) Papa, A. (GR) Rudenko, Natalia (BC-A)_{RID, ORCID} Villar, M. (ES) Alberdi, P. (ES) Torina, A. (IT) Ayllón, N. (ES) Vancová, Marie (BC-A)_{RID, ORCID} Golovchenko, Maryna (BC-A)_{RID, ORCID} Grubhoffer, Libor (BC-A)_{RID, ORCID} Caracappa, S. (IT) Fooks, A. R. (GB) Gortazar, C. (ES) Rego, Ryan O. M. (BC-A)_{RID, ORCID}
Celkový počet autorů	23
Číslo článku	114
Zdroj.dok.	Frontiers in Cellular and Infection Microbiology. - : Frontiers Media - ISSN 2235-2988 Roč. 7, APR 7 (2017)
Poč.str.	13 s.
Forma vydání	Online - E
Jazyk dok.	eng - angličtina
Země vyd.	CH - Švýcarsko
Klíč. slova	tick ; Anaplasma ; flavivirus ; Babesia ; Borrelia ; Microbiome ; immunology ; vaccine
Vědní obor RIV	EB - Genetika a molekulární biologie
Obor OECD	Biochemistry and molecular biology
Institucionální podpora	BC-A - RVO:60077344
UT WOS	000398625000001
EID SCOPUS	85027443270
DOI	10.3389/fcimb.2017.00114
Anotace	Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of the mechanisms involved in tick-pathogen interactions that affect vector competence is essential for the identification of molecular drivers for tick-borne diseases. In this review, we provide a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health. Additionally, the impact of tick microbiome on these interactions was considered. Results show that different pathogens evolved similar strategies such as manipulation of the immune response to infect vectors and facilitate multiplication and transmission. Furthermore, some of these strategies may be used by pathogens to infect both tick and mammalian hosts. Identification of interactions that promote tick survival, spread, and pathogen transmission provides the opportunity to disrupt these interactions and lead to a reduction in tick burden and the prevalence of tick-borne diseases. Targeting some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases.
Pracoviště	Biologické centrum (od r. 2006)
Kontakt	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Rok sběru	2018

Počet záznamů: 1