Počet záznamů: 1
Deformability of Microtubules: An Atomistic Computational Study
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SYSNO ASEP 0473505 Druh ASEP A - Abstrakt Zařazení RIV O - Ostatní Název Deformability of Microtubules: An Atomistic Computational Study Tvůrce(i) Kučera, Ondřej (URE-Y) RID
Havelka, Daniel (URE-Y) RID
Deriu, M.A. (CH)
Cifra, Michal (URE-Y) RID, ORCID, SAIZdroj.dok. Biophysical Journal. - : Cell Press - ISSN 0006-3495
Roč. 110, č. 3 (2016), s. 131-131Poč.str. 1 s. Forma vydání Tištěná - P Akce 60th Annual Meeting of the Biophysical-Society Datum konání 27.02.2016 - 02.03.2016 Místo konání Los Angeles Země US - Spojené státy americké Typ akce WRD Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Microtubules ; Electrical polarity Vědní obor RIV JA - Elektronika a optoelektronika, elektrotechnika CEP GA15-17102S GA ČR - Grantová agentura ČR Institucionální podpora URE-Y - RVO:67985882 UT WOS 000375093800151 DOI 10.1016/j.bpj.2015.11.751 Anotace Thanks to their material properties, microtubules can play complex variety of biological functions. Experimental studies have shown that mechanical characteristics of microtubules are length-dependent and anisotropic, however, the origin of this feature has not been traced down to the level of tubulin sequence yet. Here we use high-resolution elastic network model to show local deformations patterns in microtubule structure up to the level of individual amino acid residues. The mechanical strain within the molecular structure of a microtubule is, according to our results, localized to interdimer contacts with energetic preference of deformation in longitudinal contacts. These findings are in agreement with reported mechanical anisotropy of microtubules, i.e. higher Young's modulus in axial direction compared to radial direction. Our results contribute to understanding the origin of deformability of microtubules on the molecular level, which is important for prospective targeting of microtubules in medical therapeutic strategies Pracoviště Ústav fotoniky a elektroniky Kontakt Petr Vacek, vacek@ufe.cz, Tel.: 266 773 413, 266 773 438, 266 773 488 Rok sběru 2017
Počet záznamů: 1