Počet záznamů: 1
Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration
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SYSNO ASEP 0465951 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration Tvůrce(i) Zelenka, J. (CZ)
Dvořák, Aleš (FGU-C) ORCID, RID, SAI
Alán, Lukáš (FGU-C) RID, ORCID
Zadinová, M. (CZ)
Haluzík, M. (CZ)
Vítek, L. (CZ)Číslo článku 6190609 Zdroj.dok. Oxidative Medicine and Cellular Longevity. - : Hindawi - ISSN 1942-0900
Roč. 2016, č. 2016 (2016)Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova hyperbilirubinemia ; ROS ; senescence Vědní obor RIV EB - Genetika a molekulární biologie CEP GPP305/12/P388 GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 UT WOS 000381431600001 EID SCOPUS 84986247533 DOI 10.1155/2016/6190609 Anotace Mild constitutive hyperbilirubinemia is associated with a reduced risk of cardiovascular diseases, diabetes, and cancer. Since these pathologies are associated with aging, inflammation, and oxidative stress, we investigated whether hyperbilirubinemia interferes with ROS homeostasis in cell cultures and with inflammation, senescence, and mitochondrial dysfunction in aged rats. Human embryonic kidney cells and rat primary fibroblasts showed a dose-dependent decrease in the ratio of oxidized/reduced glutathione, intracellular H2O2 levels, and mitochondrial ROS production, with increasing bilirubin concentrations in the culture media. Compared to their normobilirubinemic siblings, aged hyperbilirubinemic Gunn rats showed significantly smaller amounts of visceral fat, better glucose tolerance, and decreased serum levels of proinflammatory cytokines TNF alpha, IL-1 beta, and IL-18. Simultaneously, livers from Gunn rats showed decreased expression of senescence markers and cell cycle inhibitors p21 and p16. Mitochondria from aged Gunn rats showed higher respiration and lower H2O2 production compared to controls. In conclusion, we demonstrated that mildly elevated serum bilirubin is generally associated with attenuation of oxidative stress and with better anthropometric parameters, decreased inflammatory status, increased glucose tolerance, fewer signs of cellular senescence, and enhanced mitochondrial function in aged rats. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2017
Počet záznamů: 1