Počet záznamů: 1
Macroporous biodegradable cryogels of synthetic poly(.alpha.-amino acids)
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SYSNO ASEP 0450082 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Macroporous biodegradable cryogels of synthetic poly(.alpha.-amino acids) Tvůrce(i) Sedlačík, Tomáš (UMCH-V) RID
Proks, Vladimír (UMCH-V) RID, ORCID
Šlouf, Miroslav (UMCH-V) RID, ORCID
Dušková-Smrčková, Miroslava (UMCH-V) RID
Studenovská, Hana (UMCH-V) RID, ORCID
Rypáček, František (UMCH-V) RIDZdroj.dok. Biomacromolecules. - : American Chemical Society - ISSN 1525-7797
Roč. 16, č. 11 (2015), s. 3455-3465Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova cryogelation ; hydrogel ; scaffold Vědní obor RIV CD - Makromolekulární chemie CEP GAP108/12/1538 GA ČR - Grantová agentura ČR Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000364614300005 EID SCOPUS 84946763643 DOI 10.1021/acs.biomac.5b01224 Anotace We present an investigation of the preparation of highly porous hydrogels based on biodegradable synthetic poly(α-amino acid) as potential tissue engineering scaffolds. Covalently cross-linked gels with permanent pores were formed under cryogenic conditions by free-radical copolymerization of poly[N5-(2-hydroxyethyl)-l-glutamine-stat-N5-(2-methacryloyl-oxy-ethyl)-l-glutamine] (PHEG-MA) with 2-hydrohyethyl methacrylate (HEMA) and, optionally, N-propargyl acrylamide (PrAAm) as minor comonomers. The morphology of the cryogels showed interconnected polyhedral or laminar pores. The volume content of communicating water-filled pores was >90%. The storage moduli of the swollen cryogels were in the range of 1–6 kPa, even when the water content was >95%. The enzymatic degradation of a cryogel corresponded to the decrease in its storage modulus during incubation with papain, a model enzyme with specificity analogous to wound-healing enzymes. It was shown that cryogels with incorporated alkyne groups can easily be modified with short synthetic peptides using azide-alkyne cycloaddition “click” chemistry, thus providing porous hydrogel scaffolds with biomimetic features. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2016
Počet záznamů: 1