Počet záznamů: 1
Protective Effects of 10-nitro-oleic Acid in a Hypoxia-Induced Murine Model of Pulmonary Hypertension
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SYSNO ASEP 0431017 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Protective Effects of 10-nitro-oleic Acid in a Hypoxia-Induced Murine Model of Pulmonary Hypertension Tvůrce(i) Klinke, A. (DE)
Moeller, A. (DE)
Pekarová, Michaela (BFU-R) RID
Ravekes, T. (DE)
Friedrichs, K. (DE)
Berlin, M. (DE)
Scheu, K.M. (DE)
Kubala, Lukáš (BFU-R) RID, ORCID
Kolářová, Hana (BFU-R) RID
Ambrožová, Gabriela (BFU-R) RID
Schermuly, R.T. (DE)
Woodcock, S.R. (US)
Freeman, B.A. (US)
Rosenkranz, S. (DE)
Baldus, S. (DE)
Rudolph, V. (DE)
Rudolph, T.K. (DE)Celkový počet autorů 17 Zdroj.dok. American Journal of Respiratory Cell and Molecular Biology - ISSN 1044-1549
Roč. 51, č. 1 (2014), s. 155-162Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova NITRO-FATTY ACIDS ; MUSCLE-CELL PROLIFERATION ; ARTERIAL-HYPERTENSION Vědní obor RIV BO - Biofyzika CEP ED1.100/02/0123 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GP13-40824P GA ČR - Grantová agentura ČR Institucionální podpora BFU-R - RVO:68081707 UT WOS 000338325300016 Anotace Pulmonary arterial hypertension (PAH) is characterized by adverse remodeling of pulmonary arteries. Although the origin of the disease and its underlying pathophysiology remain incompletely understood, inflammation has been identified as a central mediator of disease progression. Oxidative inflammatory conditions support the formation of electrophilic fatty acid nitroalkene derivatives, which exert potent anti-inflammatory effects. The current study investigated the role of 10-nitro-oleic acid (OA-NO2) in modulating the pathophysiology of PAH in mice. Mice were kept for 28 days under normoxic or hypoxic conditions, and OA-NO2 was infused subcutaneously. Right ventricular systolic pressure (RVPsys) was determined, and right ventricular and lung tissue was analyzed. The effect of OA-NO2 on cultured pulmonary artery smooth muscle cells (PASMCs) and macrophages was also investigated. Changes in RVPsys revealed increased pulmonary hypertension in mice on hypoxia, which was significantly decreased by OA-NO2 administration. Right ventricular hypertrophy and fibrosis were also attenuated by OA-NO2 treatment. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2015
Počet záznamů: 1