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Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward
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SYSNO ASEP 0399466 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward Tvůrce(i) de Oliveira, A. M. (BR)
Jäger, Eliezer (UMCH-V) ORCID, RID
Jäger, Alessandro (UMCH-V) RID, ORCID
Štěpánek, Petr (UMCH-V) RID, ORCID
Giacomelli, F. C. (BR)Zdroj.dok. Colloids and Surfaces A-Physicochemical and Engineering Aspects. - : Elsevier - ISSN 0927-7757
Roč. 436, 5 September (2013), s. 1092-1102Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova sub-100 nm polymeric nanoparticles ; light scattering ; nanoprecipitation Vědní obor RIV BO - Biofyzika CEP GA202/09/2078 GA ČR - Grantová agentura ČR Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000326416900135 DOI 10.1016/j.colsurfa.2013.08.056 Anotace Surfactant-free PLGA polymeric nanoparticles (PNPs) with hydrodynamic radius (RH) ranging from 25.8 nm to 128.5 nm were successfully obtained through nanoprecipitation by controlling a variety of physicochemical parameters. The size of the generated PLGA PNPs could be controlled by adjusting the polymer concentration, the choice of organic solvent, mixing different organic solvents or by changing temperature and ionic strength. By optimizing such parameters sub-100 nm uniform PNPs can be produced through this methodology including the advantage and ability to scale-up production. The PNPs have shown a size-dependent effect on the organic solvent and polymer concentration. On the other hand, the polymer–solvent interactions seem not to play a substantial role in the final dimension of the polymer colloids. It has been also evidenced that the size of PNPs can be precisely and linearly tuned by using solvent mixtures as organic phase. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2014
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