Synthesis of PME derivatives on nucleobases with conformation locked via pyrrolidine ring

0361527 - ÚOCHB 2012 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Rejman, Dominik - Pohl, Radek
Synthesis of PME derivatives on nucleobases with conformation locked via pyrrolidine ring.
Chemistry of Nucleic Acid Components. 15th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i., 2011 - (Hocek, M.), s. 446-447. Collection Symposium Series, 12. ISBN 978-80-86241-37-1.
[Chemistry of Nucleic Acid Components /15./. Český Krumlov (CZ), 05.06.2011-10.06.2011]
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: PME derivatives * locked conformation * nucleoside phosphonic acids * conformationally locked nucleotides * pyrrolidine ring
Kód oboru RIV: CC - Organická chemie

Among diverse nucleoside phosphonic acids, the acyclic phosphonate derivatives have been earlier shown to involve some exceptionally potent antiviral drugs (e.g., Cidofovir, Adefovir, and Tenofovir). This work presents the synthesis of such acyclic phosphonate nucleotides conformationally locked via pyrrolidine ring.
Trvalý link: http://hdl.handle.net/11104/0198824