Počet záznamů: 1  

Development of spray-dried powder hand sanitiser with prolonged effectivity.

  1. 1.
    SYSNO ASEP0583944
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevDevelopment of spray-dried powder hand sanitiser with prolonged effectivity.
    Tvůrce(i) Večerková, L. (CZ)
    Mašková, L. (CZ)
    Knejzlík, Zdeněk (UOCHB-X)
    Kašpar, O. (CZ)
    Tokárová, V. (CZ)
    Číslo článku4827
    Zdroj.dok.Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
    Roč. 14, February (2024)
    Poč.str.15 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovachlorhexidine ; ingredients ; efficacy
    Způsob publikováníOpen access
    Institucionální podporaUOCHB-X - RVO:61388963
    UT WOS001177590700004
    EID SCOPUS85186196817
    DOI10.1038/s41598-024-55503-w
    AnotaceSince the outbreak of the COVID-19 pandemic, the use of hand sanitisers has become an inseparable part of our personal hygiene. However, the short-term effect and the need for frequent application are shortcomings that impair the overall protection. Another aspect is that repeated use of some products (typically alcohol-based) may cause skin irritation or eventually more severe health problems. This work proposes spray-drying as a suitable method for the preparation of swellable chitosan carriers, allowing for encapsulation and sustained release of antibacterial chlorhexidine digluconate as a model active substance. After application to hands, micron-sized particles preferentially accommodate space between epidermal ridges, protected against attrition. Thanks to their small size (d<10m), particles are comfortable to carry since they are not recognisable by somatosensory receptors. The performance of formulations with various amounts of chlorhexidine and cross-linker was tested and compared with selected commercial disinfectants available on the Czech market (ethanol gel and alcoholic solution with chlorhexidine) against E. coli and S. epidermidis. The real-life performance was investigated with twelve volunteers performing various activities for up to 2h. Finally, a replica of the human index finger with accurately captured micro-topology was proposed and compared with volunteers' fingers concerning the total amount of adhered and detached particles.
    PracovištěÚstav organické chemie a biochemie
    Kontaktasep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
    Rok sběru2025
    Elektronická adresahttps://doi.org/10.1038/s41598-024-55503-w
Počet záznamů: 1  

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