Počet záznamů: 1
Current therapeutic targets and multifaceted physiological impacts of caffeine
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SYSNO ASEP 0582877 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Current therapeutic targets and multifaceted physiological impacts of caffeine Tvůrce(i) Song, X. (CN)
Kirtipal, N. (KR)
Lee, S. (KR)
Malý, Petr (BTO-N) RID, ORCID
Bharadwaj, Shiv (BTO-N)Celkový počet autorů 5 Zdroj.dok. Phytotherapy Research - ISSN 0951-418X
Roč. 37, č. 12 (2023), s. 5558-5598Poč.str. 41 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova dependent protein-kinase ; blood-brain-barrier ; habitual coffee consumption ; pharmacology Vědní obor RIV FR - Farmakologie a lékárnická chemie Obor OECD Pharmacology and pharmacy Způsob publikování Open access Institucionální podpora BTO-N - RVO:86652036 UT WOS 001059890800001 EID SCOPUS 85170287051 DOI 10.1002/ptr.8000 Anotace Caffeine, which shares consubstantial structural similarity with purine adenosine, has been demonstrated as a nonselective adenosine receptor antagonist for eliciting most of the biological functions at physiologically relevant dosages. Accumulating evidence supports caffeine's beneficial effects against different disorders, such as total cardiovascular diseases and type 2 diabetes. Conversely, paradoxical effects are also linked to caffeine ingestion in humans including hypertension-hypotension and tachycardia-bradycardia. These observations suggest the association of caffeine action with its ingested concentration and/or concurrent interaction with preferential molecular targets to direct explicit events in the human body. Thus, a coherent analysis of the functional targets of caffeine, relevant to normal physiology, and disease pathophysiology, is required to understand the pharmacology of caffeine. This review provides a broad overview of the experimentally validated targets of caffeine, particularly those of therapeutic interest, and the impacts of caffeine on organ-specific physiology and pathophysiology. Overall, the available empirical and epidemiological evidence supports the dose-dependent functional activities of caffeine and advocates for further studies to get insights into the caffeine-induced changes under specific conditions, such as asthma, DNA repair, and cancer, in view of its therapeutic applications. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2024 Elektronická adresa https://onlinelibrary.wiley.com/doi/10.1002/ptr.8000
Počet záznamů: 1