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Lithiated porous silicon nanowires stimulate periodontal regeneration
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SYSNO ASEP 0582132 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Lithiated porous silicon nanowires stimulate periodontal regeneration Tvůrce(i) Kaasalainen, M. (FI)
Zhang, R. (CN)
Vashisth, P. (GB)
Birjandi, A. A. (GB)
S'Ari, M. (GB)
Martella, D. A. (GB)
Isaacs, M. (GB)
Makila, E. (FI)
Wang, C. (CN)
Moldenhauer, E. (DE)
Clarke, P. (DE)
Pinna, A. (GB)
Zhang, X. (GB)
Mustfa, S. A. (GB)
Caprettini, V. (GB)
Morrell, A. P. (GB)
Gentleman, E. (GB)
Brauer, D. S. (DE)
Addison, O. (GB)
Zhang, X. (CN)
Bergholt, M. (GB)
Al-Jamal, K. (GB)
Volponi, A. A. (GB)
Salonen, J. (FI)
Hondow, N. (GB)
Sharpe, Paul (UZFG-Y)
Chiappini, C. (GB)Celkový počet autorů 27 Číslo článku 487 Zdroj.dok. Nature Communications. - : Nature Publishing Group
Roč. 15, č. 1 (2024)Poč.str. 16 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova signaling pathway ; lithium ; activation ; differentiation ; anode ; glass ; nanoparticles ; bioactivity Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Cell biology CEP GA21-21409S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 001142873900011 EID SCOPUS 85182177983 DOI 10.1038/s41467-023-44581-5 Anotace Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/beta-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy developed for battery technology, can introduce large, controllable amounts of lithium within porous silicon, but yields a highly reactive material, unsuitable for biomedicine. This work debuts a strategy to lithiate porous silicon nanowires (LipSiNs) which generates a biocompatible and bioresorbable material. LipSiNs incorporate lithium to between 1% and 40% of silicon content, releasing lithium and silicic acid in a tailorable fashion from days to weeks. LipSiNs combine osteogenic, cementogenic and Wnt/beta-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine periodontal defect. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2025 Elektronická adresa https://www.nature.com/articles/s41467-023-44581-5
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