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Oligo(ethylene glycol) methyl ether methacrylate based hydrogel with intrinsic antibacterial activity against Pseudomonas aeruginosa as a model of a major wound infecting human pathogen
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SYSNO ASEP 0580777 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Oligo(ethylene glycol) methyl ether methacrylate based hydrogel with intrinsic antibacterial activity against Pseudomonas aeruginosa as a model of a major wound infecting human pathogen Tvůrce(i) Cetinkaya, A. (PL)
Kissmann, A.-K. (DE)
Lipinska, M. (PL)
Trzaskowska, M. (PL)
Duniec, J. (PL)
Katariya, H. (PL)
Šlouf, Miroslav (UMCH-V) RID, ORCID
Herberger, T. (DE)
Weil, T. (DE)
Przekora, A. (PL)
Rosenau, F. (DE)
Pietrasik, J. (PL)Číslo článku 112758 Zdroj.dok. European Polymer Journal. - : Elsevier - ISSN 0014-3057
Roč. 205, 7 February (2024)Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova biocidal surfaces ; wound healing ; quaternization Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 001164197000001 EID SCOPUS 85182518384 DOI 10.1016/j.eurpolymj.2024.112758 Anotace Wound dressings represent the first important defense line against potentially life-threatening infections. Successful materials should unify efficiency, simplicity of production with the ease of application. Cationic polymers based on quaternary ammonium salt moieties along the polymer chain promise high efficacy against growth of relevant pathogens including drug-resistant strains. We present a novel and easy-to-handle wound dressing material based on the well-defined copolymers of oligo(ethylene glycol) methyl ether methacrylate (OEGMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA), using quaternization with 1,6-dibromohexane for hydrogel formation. The material obtained from this robust approach was perfectly biocompatible with human dermal fibroblasts and revealed an auspicious degree of intrinsic antibacterial activity against P. aeruginosa as a model pathogen for hospital-acquired infections. Formation of bacterial biofilms was prevented in early- and late-stages and even planktonic cells were killed upon gel contact. The rheological properties of the hydrogel materials were comprehensively characterized in both dry and swollen states. Excellent biological performance and appropriate viscoelastic properties qualify the hydrogels from our production approach as truly promising novel wound dressing materials with long-lasting and contact-active bactericidal activities. We believe that this charmingly simple procedure and the mechanical properties of the hydrogel may open new avenues towards cost-effective next-generation first-line wound-care materials. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2025 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0014305724000193?via%3Dihub
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