Počet záznamů: 1
Effects of various environments on epigenetic settings and chromosomal damage
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SYSNO ASEP 0580305 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Effects of various environments on epigenetic settings and chromosomal damage Tvůrce(i) Rössnerová, Andrea (UEM-P) RID
Elzeinová, Fatima (UEM-P)
Chvojková, Irena (UEM-P)
Hoňková, Kateřina (UEM-P)
Šíma, Michal (UEM-P) RID, ORCID
Milcová, Alena (UEM-P)
Pastorková, Anna (UEM-P) RID
Schmuczerová, Jana (UEM-P) RID
Rössner ml., Pavel (UEM-P) RID, ORCID
Topinka, Jan (UEM-P) RID, ORCID
Šrám, Radim (UEM-P) RIDČíslo článku 121290 Zdroj.dok. Environmental Pollution. - : Elsevier - ISSN 0269-7491
Roč. 323, apr (2023)Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova air pollution ; chronical exposure ; epigenetic adaptation ; micronuclei ; chromosomal breaks ; NHEJ repair Obor OECD Public and environmental health CEP EF16_019/0000798 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LM2018124 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LM2018133 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy EF16_013/0001821 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 000953151900001 EID SCOPUS 85148719802 DOI 10.1016/j.envpol.2023.121290 Anotace Air pollution is a dominant environmental exposure factor with significant health consequences. Unexpectedly, research in a heavily polluted region of the Czech Republic, with traditional heavy industry, revealed repeatedly the lowest frequency of micronuclei in the season with the highest concentrations of air pollutants including carcinogenic benzo[a]pyrene (B[a]P). Molecular findings have been collected for more than 10 years from various locations of the Czech Republic, with differing quality of ambient air. Preliminary conclusions have suggested adaptation of the population from the polluted locality (Ostrava, Moravian-Silesian Region (MSR)) to chronic air pollution exposure. In this study we utilize the previous findings and, for the first time, investigate micronuclei (MN) frequency by type: (i) centromere positive (CEN+) MN, representing chromosomal losses, and (ii) centromere negative (CEN-) MN representing chromosomal breaks. As previous results indicated differences between populations in the expression of XRCC5, a gene involved in the non-homologous end-joining (NHEJ) repair pathway, possible variations in epigenetic settings in this gene were also investigated. This new research was conducted in two seasons in the groups from two localities with different air quality levels (Ostrava (OS) and Prague (PG)). The obtained new results show significantly lower frequencies of chromosomal breaks in the OS subjects, related to the highest air pollution levels (p < 0.001). In contrast, chromosomal losses were comparable between both groups. In addition, significantly lower DNA methylation was found in 14.3% of the analyzed CpG loci of XRCC5 in the population from OS. In conclusion, the epigenetic adaptation (hypomethylation) in XRCC5 involved in the NHEJ repair pathway in the population from the polluted region, was suggested as a reason for the reduced level of chromosomal breaks. Further research is needed to explore the additional mechanisms, including genetic adaptation. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2024 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0269749123002920?via%3Dihub
Počet záznamů: 1