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One-pot/simultaneous synthesis of PHPMA-g-PLA copolymers via metal-free ROP/RAFT polymerization and their self-assembly from micelles to thermoresponsive vesicles
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SYSNO ASEP 0579131 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název One-pot/simultaneous synthesis of PHPMA-g-PLA copolymers via metal-free ROP/RAFT polymerization and their self-assembly from micelles to thermoresponsive vesicles Tvůrce(i) Lukáš Petrova, Svetlana (UMCH-V) ORCID, RID
Sincari, Vladimir (UMCH-V) ORCID, RID
Konefal, Rafal (UMCH-V) RID, ORCID
Pavlova, Ewa (UMCH-V) RID
Lobaz, Volodymyr (UMCH-V) RID, ORCID
Kočková, Olga (UMCH-V) RID, ORCID
Hrubý, Martin (UMCH-V) RID, ORCIDČíslo článku 2300271 Zdroj.dok. Macromolecular Chemistry and Physics. - : Wiley - ISSN 1022-1352
Roč. 224, č. 23 (2023)Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova graft copolymers ; nanoparticles ; one-pot/one-step RAFT/ROP synthesis Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP GA21-01090S GA ČR - Grantová agentura ČR LM2018133 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 001091321100001 EID SCOPUS 85174948309 DOI 10.1002/macp.202300271 Anotace The present article reports a simple and straightforward approach to access thermoresponsive graft copolymers based on lactide (LA) and a methacrylic monomer, 2-hydroxypropyl methacrylate (HPMA), using a synthesized carboxy-functionalized trithiocarbonate-based chain transfer agent. One protocol involves a metal-free simultaneous synthesis through a combination of reversible addition-fragmentation chain transfer polymerization and organic acid-catalyzed ring-opening polymerization, which follows first-order kinetics. The resulting copolymers with a controlled structure exhibit remarkably narrow molecular weight distributions (Ð < 1.10). Within this framework, the self-assembly of PHPMA-g-PLA graft copolymers (GCs) into nanoparticles (NPs) is demonstrated at concentrations of 0.2 and 0.5 wt.%, respectively. The displacement method, based on the rapid injection of the organic solvent (acetone) into an aqueous medium under vigorous stirring, produces spherical NPs such as micelles, vesicles, or non-spherical “lumpy rods”. The presence of a pseudo-thermoresponsive segment (PHPMA) in GCs facilitates stimulus-responsive self-assembly behavior. Well-defined spherical NPs—primarily vesicles of substantial size—develop upon heating above the glass transition temperature (Tg ≈35–36 °C) of the GCs in an acetone–water (80/20 wt.%) mixture. Last, specific interactions between the obtained PHPMA-g-PLA nano-objects and blood proteins in human plasma are studied using isothermal calorimetry. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2024 Elektronická adresa https://onlinelibrary.wiley.com/doi/10.1002/macp.202300271
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