Počet záznamů: 1
Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum
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SYSNO ASEP 0574500 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum Tvůrce(i) Kurogi, Y. (JP)
Imura, E. (US)
Mizuno, Y. (JP)
Hoshino, R. (JP)
Nouzová, Marcela (BC-A) ORCID
Matsuyama, S. (JP)
Mizoguchi, A. (JP)
Kondo, S. (JP)
Tanimoto, H. (JP)
Noriega, F. G. (US)
Niwa, R. (JP)Celkový počet autorů 11 Číslo článku dev201186 Zdroj.dok. Development. - : Company of Biologists - ISSN 0950-1991
Roč. 150, č. 10 (2023)Poč.str. 14 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Reproductive dormancy ; Diapause ; Juvenile hormone ; Corpus allatum ; Diuretic hormone 31 ; Drosophila Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology CEP GA22-21244S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora BC-A - RVO:60077344 UT WOS 001013373500002 EID SCOPUS 85159836236 DOI 10.1242/dev.201186 Anotace Female insects can enter reproductive diapause, a state of suspended egg development, to conserve energy under adverse environments. In many insects, including the fruit fly, Drosophila melanogaster, reproductive diapause, also frequently called reproductive dormancy, is induced under low-temperature and short-day conditions by the downregulation of juvenile hormone (JH) biosynthesis in the corpus allatum (CA). In this study, we demonstrate that neuropeptide Diuretic hormone 31 (DH31) produced by brain neurons that project into the CA plays an essential role in regulating reproductive dormancy by suppressing JH biosynthesis in adult D. melanogaster. The CA expresses the gene encoding the DH31 receptor, which is required for DH31-triggered elevation of intracellular cAMP in the CA. Knocking down Dh31 in these CA-projecting neurons or DH31 receptor in the CA suppresses the decrease of JH titer, normally observed under dormancy-inducing conditions, leading to abnormal yolk accumulation in the ovaries. Our findings provide the first molecular genetic evidence demonstrating that CA-projecting peptidergic neurons play an essential role in regulating reproductive dormancy by suppressing JH biosynthesis. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2024 Elektronická adresa https://journals.biologists.com/dev/article/150/10/dev201186/310536/Female-reproductive-dormancy-in-Drosophila-is
Počet záznamů: 1