Počet záznamů: 1
Serum matrix metalloproteinase-9 (MMP-9) as a biomarker in paediatric and adult tick-borne encephalitis patients
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SYSNO ASEP 0569304 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Serum matrix metalloproteinase-9 (MMP-9) as a biomarker in paediatric and adult tick-borne encephalitis patients Tvůrce(i) Fořtová, A. (CZ)
Hönig, Václav (BC-A) RID, ORCID
Salát, Jiří (BC-A) RID, ORCID
Palus, Martin (BC-A) RID, ORCID
Pychova, M. (CZ)
Krbková, L. (CZ)
Barkhash, A. (RU)
Kříha, M.F. (CZ)
Chrdle, A. (CZ)
Lipoldová, Marie (UMG-J) RID
Růžek, Daniel (BC-A) RID, ORCIDCelkový počet autorů 11 Číslo článku 199020 Zdroj.dok. Virus Research. - : Elsevier - ISSN 0168-1702
Roč. 324, JAN (2023)Poč.str. 8 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Tick-borne encephalitis ; Neuroinfection ; Matrix matalloproteinase ; Cerebrospinal fluid Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Virology Vědní obor RIV – spolupráce Ústav molekulární genetiky CEP GA20-14325S GA ČR - Grantová agentura ČR GA20-30500S GA ČR - Grantová agentura ČR NV19-05-00457 GA MZd - Ministerstvo zdravotnictví Způsob publikování Omezený přístup Institucionální podpora BC-A - RVO:60077344 ; UMG-J - RVO:68378050 UT WOS 000920459100001 EID SCOPUS 85145704854 DOI 10.1016/j.virusres.2022.199020 Anotace Matrix metalloproteinases (MMPs) play an important role in central nervous system infections. We analysed the levels of 8 different MMPs in the cerebrospinal fluid (CSF) of 89 adult patients infected with tick-borne encephalitis (TBE) virus and compared them with the levels in a control group. MMP-9 was the only MMP that showed significantly increased CSF levels in TBE patients. Serum MMP-9 levels were subsequently measured in 101 adult TBE patients at various time points during the neurological phase of TBE and at follow-up. In addition, serum MMP-9 was analysed in 37 paediatric TBE patients. Compared with control levels, both paediatric and adult TBE patients had significantly elevated serum MMP-9 levels. In most adult patients, serum MMP-9 levels peaked at hospital admission, with higher serum MMP-9 levels observed in patients with encephalitis than in patients with meningitis. Elevated serum MMP-9 levels were observed throughout hospitalisation but decreased to normal levels at follow-up. Serum MMP-9 levels correlated with clinical course, especially in patients heterozygous for the single-nucleotide polymorphism rs17576 (A/G, Gln279Arg) in the MMP9 gene. The results highlight the importance of MMP-9 in the pathogenesis of TBE and suggest that serum MMP-9 may serve as a promising bioindicator of TBE in both paediatric and adult TBE patients. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2024 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0168170222003495?via%3Dihub
Počet záznamů: 1