Počet záznamů: 1
Development and diseases of the coronary microvasculature and its communication with the myocardium
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SYSNO ASEP 0561349 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Development and diseases of the coronary microvasculature and its communication with the myocardium Tvůrce(i) Neffeová, K. (CZ)
Olejníčková, Veronika (FGU-C) RID, ORCID, SAI
Naňka, O. (CZ)
Kolesová, Hana (FGU-C) RID, ORCID, SAIČíslo článku e1560 Zdroj.dok. WIREs Mechanisms of Disease - ISSN 2692-9368
Roč. 14, č. 5 (2022)Poč.str. 23 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova coronary microvasculature ; coronary vessels ; heart development ; myocardium ; pulmonary atresia Obor OECD Cardiac and Cardiovascular systems CEP NU21-02-00402 GA MZd - Ministerstvo zdravotnictví GA18-03207S GA ČR - Grantová agentura ČR GA18-03461S GA ČR - Grantová agentura ČR LTC17023 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LM2015062 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000814053100001 EID SCOPUS 85138047872 DOI 10.1002/wsbm.1560 Anotace We review the current understanding of formation and development of the coronary microvasculature which supplies oxygen and nutrients to the heart myocardium and removes waste. We emphasize the close relationship, mutual development, and communication between microvasculature endothelial cells and surrounding cardiomyocytes. The first part of the review is focused on formation of microvasculature during embryonic development. We summarize knowledge about establishing the heart microvasculature density based on diffusion distance. Then signaling mechanisms which are involved in forming the microvasculature are discussed. This includes details of cardiomyocyte-endothelial cell interactions involving hypoxia, VEGF, NOTCH, angiopoietin, PDGF, and other signaling factors. The microvasculature is understudied due to difficulties in its visualization. Therefore, currently available imaging methods to delineate the coronary microvasculature in development and in adults are discussed. The second part of the review is dedicated to the importance of the coronary vasculature in disease. Coronary microvasculature pathologies are present in many congenital heart diseases (CHD), especially in pulmonary atresia, and worsen outcomes. In CHDs, where the development of the myocardium is impaired, microvasculature is also affected. In adult patients coronary microvascular disease is one of the main causes of sudden cardiac death, especially in women. Coronary microvasculature pathologies affect myocardial ischemia and vice versa, myocardial pathologies such as cardiomyopathies are closely connected with coronary microvasculature dysfunction. Microvasculature inflammation also worsens the outcomes of COVID-19 disease. Our review stresses the importance of coronary microvasculature and provides an overview of its formation and signaling mechanisms and the importance of coronary vasculature pathologies in CHDs and adult diseases. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://doi.org/10.1002/wsbm.1560
Počet záznamů: 1