Počet záznamů: 1
Avenue to X-ray-induced photodynamic therapy of prostatic carcinoma with octahedral molybdenum cluster nanoparticles
- 1.
SYSNO ASEP 0559289 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Avenue to X-ray-induced photodynamic therapy of prostatic carcinoma with octahedral molybdenum cluster nanoparticles Tvůrce(i) Koncošová, M. (CZ)
Rumlová, M. (CZ)
Mikyšková, Romana (UMG-J) RID
Reiniš, Milan (UMG-J) RID
Zelenka, J. (CZ)
Ruml, T. (CZ)
Kirakci, Kaplan (UACH-T) SAI, RID, ORCID
Lang, Kamil (UACH-T) SAI, RID, ORCIDCelkový počet autorů 8 Zdroj.dok. Journal of Materials Chemistry B - ISSN 2050-750X
Roč. 10, č. 17 (2022), s. 3303-3310Poč.str. 8 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova cancer ; BR Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemistry and molecular biology CEP GA21-11688S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UMG-J - RVO:68378050 ; UACH-T - RVO:61388980 UT WOS 000778336400001 EID SCOPUS 85129173177 DOI 10.1039/d2tb00141a Anotace X-Ray-induced photodynamic therapy represents a suitable modality for the treatment of various malignancies. It is based on the production of reactive oxygen species by radiosensitizing nanoparticles activated by X-rays. Hence, it allows overcoming the depth-penetration limitations of conventional photodynamic therapy and, at the same time, reducing the dose needed to eradicate cancer in the frame of radiotherapy treatment. The direct production of singlet oxygen by octahedral molybdenum cluster complexes upon X-ray irradiation is a promising avenue in order to simplify the architecture of radiosensitizing systems. One such complex was utilized to prepare water-stable nanoparticles using the solvent displacement method. The nanoparticles displayed intense red luminescence in aqueous media, efficiently quenched by oxygen to produce singlet oxygen, resulting in a substantial photodynamic effect under blue light irradiation. A robust radiosensitizing effect of the nanoparticles was demonstrated in vitro against TRAMP-C2 murine prostatic carcinoma cells at typical therapeutic X-ray doses. Injection of a suspension of the nanoparticles to a mouse model revealed the absence of acute toxicity as evidenced by the invariance of key physiological parameters. This study paves the way for the application of octahedral molybdenum cluster-based radiosensitizers in X-ray-induced photodynamic therapy and its translation to in vivo experiments. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2023 Elektronická adresa https://pubs.rsc.org/en/content/articlelanding/2022/tb/d2tb00141a
Počet záznamů: 1