Počet záznamů: 1
Evaluation of estrogenic and antiestrogenic activity in sludge and explanation of individual compound contributions
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SYSNO ASEP 0557651 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Evaluation of estrogenic and antiestrogenic activity in sludge and explanation of individual compound contributions Tvůrce(i) Černá, Tereza (MBU-M)
Ezechiáš, Martin (MBU-M) RID
Semerád, Jaroslav (MBU-M) ORCID, RID
Grasserová, Alena (MBU-M) ORCID
Cajthaml, Tomáš (MBU-M) RID, ORCIDČíslo článku 127108 Zdroj.dok. Journal of Hazardous Materials. - : Elsevier - ISSN 0304-3894
Roč. 423, FEB 5 2022 (2022)Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova effect-directed analysis ; municipal waste-water ; generalized concentration addition ; reporter gene assay ; sewage-sludge ; bisphenol analogs ; environmental estrogens ; androgenic activity ; endocrine activity ; steroid estrogens ; WWTP sludge ; Mixture toxicity ; Constructed wetland ; Agonistic activity ; Antagonistic activity Vědní obor RIV EH - Ekologie - společenstva Obor OECD Environmental sciences (social aspects to be 5.7) Způsob publikování Omezený přístup Institucionální podpora MBU-M - RVO:61388971 UT WOS 000696981500003 EID SCOPUS 85114679051 DOI 10.1016/j.jhazmat.2021.127108 Anotace Mixture toxicity, including agonistic and antagonistic effects, is an unrevealed environmental problem. Estrogenic endocrine disruptors are known to cause adverse effects for aquatic biota, but causative chemicals and their contributions to the total activity in sewage sludge remain unknown. Therefore, advanced analytical methods, a yeast bioassay and mixture toxicity models were concurrently applied for the characterization of 8 selected sludges with delectable estrogenic activity (and 3 sludges with no activity as blanks) out of 25 samples from wastewater treatment plants (WWTPs). The first applied full logistic model adequately explained total activity by considering the concentrations of the monitored compounds. The results showed that the activity was primarily caused by natural estrogens in municipal WWTP sludge. Nevertheless, activity in a sample originating from a car wash facility was dominantly caused by partial agonists nonylphenols and only a model enabling prediction of all dose-response curve parameters of the final mixture curve explained these results. Antiestrogenic effects were negligible, and effect-directed analysis identified the causative chemicals. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2023 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0304389421020768?via%3Dihub
Počet záznamů: 1