Počet záznamů: 1
Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy.
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SYSNO ASEP 0552512 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy. Tvůrce(i) Breinlinger, S. (DE)
Phillips, T. J. (US)
Haram, B. N. (US)
Mareš, Jan (BC-A) RID, ORCID
Yerena, Jose Alberto Martinez (BC-A)
Hrouzek, P. (CZ)
Sobotka, R. (CZ)
Henderson, W. M. (US)
Schmieder, P. (DE)
Williams, S. M. (US)
Lauderdale, J. D. (US)
Wilde, H. D. (US)
Gerrin, W. (US)
Kust, Andreja (BC-A) RID, ORCID
Washington, J. W. (US)
Wagner, C. (DE)
Geier, B. (DE)
Liebeke, M. (DE)
Enke, H. (DE)
Niedermeyer, T. H. J. (DE)
Wilde, S. B. (US)Celkový počet autorů 21 Zdroj.dok. Science. - : American Association for the Advancement of Science - ISSN 0036-8075
Roč. 371, č. 6536 (2021), s. 1335-+Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Neurological diesease ; Cyanobacteria ; Toxin Vědní obor RIV DA - Hydrologie a limnologie Obor OECD Marine biology, freshwater biology, limnology CEP GC19-21649J GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora BC-A - RVO:60077344 UT WOS 000636043400031 EID SCOPUS 85116827651 DOI 10.1126/science.aax9050 Anotace Vacuolar myelinopathy is a fatal neurological disease that was initially discovered during a mysterious mass mortality of bald eagles in Arkansas in the United States. The cause of this wildlife disease has eluded scientists for decades while its occurrence has continued to spread throughout freshwater reservoirs in the southeastern United States. Recent studies have demonstrated that vacuolar myelinopathy is induced by consumption of the epiphytic cyanobacterial species Aetokthonos hydrillicola growing on aquatic vegetation, primarily the invasive Hydrilla verticillata. Here, we describe the identification, biosynthetic gene cluster, and biological activity of aetokthonotoxin, a pentabrominated biindole alkaloid that is produced by the cyanobacterium A. hydrillicola. We identify this cyanobacterial neurotoxin as the causal agent of vacuolar myelinopathy and discuss environmental factors-especially bromide availability-that promote toxin production. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2022 Elektronická adresa https://doi.org/10.1126/science.aax9050
Počet záznamů: 1