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Cashew gum (Anacardium occidentale) as a potential source for the production of tocopherol-loaded nanoparticles: formulation, release profile and cytotoxicity
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SYSNO ASEP 0545483 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cashew gum (Anacardium occidentale) as a potential source for the production of tocopherol-loaded nanoparticles: formulation, release profile and cytotoxicity Tvůrce(i) Loureiro, Kahynna Cavalcante (UMCH-V)
Jäger, Alessandro (UMCH-V) RID, ORCID
Pavlova, Ewa (UMCH-V) RID
Lima-Verde, I. B. (SE)
Štěpánek, Petr (UMCH-V) RID, ORCID
Sangenito, L. S. (BR)
Santos, A. L. S. (BR)
Chaud, M. V. (BR)
Barud, H. S. (BR)
Soares, M. F. La R. (BR)
de Albuquerque-Júnior, R. L. C. (BR)
Cardoso, J. C. (BR)
Souto, E. B. (PT)
da Costa Mendonca, M. (BR)
Severino, P. (BR)Číslo článku 8467 Zdroj.dok. Applied Sciences-Basel. - : MDPI
Roč. 11, č. 18 (2021)Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova cashew gum ; nanoparticles ; tocopherol Vědní obor RIV JP - Průmyslové procesy a zpracování Obor OECD Materials engineering CEP GJ20-13946Y GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000699570300001 EID SCOPUS 85114924144 DOI 10.3390/app11188467 Anotace Every year, more than thirty thousand tons of Cashew gum (Anacardium occidentale, family: Anacardiaceae) are produced in Brazil. Only a small amount is used for different applications in foodstuff and in pharmaceutical industries. As a raw material for the production of drug delivery systems, cashew gum is still regarded as an innovative compound worth to be exploited. In this work, cashew gum was extracted from the crude exudate of cashew tree employing four methodologies resulting in a light brown powder in different yields (40.61% to 58.40%). The total ashes (0.34% to 1.05%) and moisture (12.90% to 14.81%) were also dependent on the purification approach. FTIR spectra showed the typical bands of purified cashew gum samples, confirming their suitability for the development of a pharmaceutical product. Cashew gum nanoparticles were produced by nanoprecipitation resulting in particles of low polydispersity (<0.2) and an average size depending on the percentage of the oil. The zeta potential of nanoparticles was found to be below 20 mV, which promotes electrostatic stability. Encapsulation efficiencies were above 99.9%, while loading capacity increased with the increase of the percentage of the oil content of particles. The release of the oil from the nanoparticles followed the Korsmeyer–Peppas kinetics model, while particles did not show any signs of toxicity when tested in three distinct cell lines (LLC-MK2, HepG2, and THP-1). Our study highlights the potential added value of using a protein-, lignans-, and nucleic acids-enriched resin obtained from crude extract as a new raw material for the production of drug delivery systems. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2022 Elektronická adresa https://www.mdpi.com/2076-3417/11/18/8467
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