Počet záznamů: 1
Small protease inhibitors in tick saliva and salivary glands and their role in tick-host-pathogen interactions
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SYSNO ASEP 0538674 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Small protease inhibitors in tick saliva and salivary glands and their role in tick-host-pathogen interactions Tvůrce(i) Martins, Larissa Almeida (BC-A) RID, ORCID
Kotál, Jan (BC-A) RID, ORCID
Bensaoud, Chaima (BC-A) RID, ORCID
Chmelař, J. (CZ)
Kotsyfakis, Michalis (BC-A) RID, ORCIDCelkový počet autorů 5 Číslo článku 140336 Zdroj.dok. Biochimica Et Biophysica Acta-Proteins and Proteomics. - : Elsevier - ISSN 1570-9639
Roč. 1868, č. 2 (2020)Poč.str. 10 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova factor pathway inhibitor ; kunitz-type inhibitor ; ixodes-scapularis ; soft tick ; functional-characterization ; transcriptome analysis ; factor-xa ; haemaphysalis-longicornis ; differential expression ; ornithodoros-moubata ; Cystatins ; Kunitz-domain proteins ; Protease inhibitor ; Saliva ; Salivary gland ; Sialomes ; Tick-host-pathogen Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology CEP GA19-07247S GA ČR - Grantová agentura ČR EF16_019/0000759 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora BC-A - RVO:60077344 UT WOS 000508739900018 EID SCOPUS 85076473664 DOI 10.1016/j.bbapap.2019.140336 Anotace Ticks must durably suppress vertebrate host responses (hemostasis, inflammation, immunity) to avoid rejection and act as vectors of many pathogenic microorganisms that cause disease in humans and animals. Transcriptomics and proteomics studies have been used to study tick-host-pathogen interactions and have facilitated the systematic characterization of salivary composition and molecular dynamics throughout tick feeding. Tick saliva contains a complement of protease inhibitors that are differentially produced during feeding, many of which inhibit blood coagulation, platelet aggregation, vasodilation, and immunity. Here we focus on two major groups of protease inhibitors, the small molecular weight Kunitz inhibitors and cystatins. We discuss their role in tick-host-pathogen interactions, how they mediate the interaction between ticks and their hosts, and how they might be exploited both by pathogens to invade hosts and as candidates for the treatment of various human pathologies. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2021 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S1570963919302213?via%3Dihub
Počet záznamů: 1