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No evidence for accumulation of deleterious mutations and fitness degradation in clonal fish hybrids: Abandoning sex without regrets
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SYSNO ASEP 0531707 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název No evidence for accumulation of deleterious mutations and fitness degradation in clonal fish hybrids: Abandoning sex without regrets Tvůrce(i) Kočí, Jan (UZFG-Y)
Röslein, Jan (UZFG-Y)
Pačes, Jan (UZFG-Y)
Kotusz, J. (PL)
Halačka, Karel (UBO-W) RID, SAI
Koščo, J. (SK)
Fedorčák, J. (SK)
Iakovenko, Nataliia (UZFG-Y) ORCID
Janko, Karel (UZFG-Y) RID, ORCIDZdroj.dok. Molecular Ecology. - : Wiley - ISSN 0962-1083
Roč. 29, č. 16 (2020), s. 3038-3055Poč.str. 18 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova asexuality ; clonal decay ; exome capture ; fitness ; Muller´s ratchet ; mutation load Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology Vědní obor RIV – spolupráce Ústav biologie obratlovců - Ekologie - společenstva CEP GA13-12580S GA ČR - Grantová agentura ČR LM2015047 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy EF15_003/0000460 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UZFG-Y - RVO:67985904 ; UBO-W - RVO:68081766 UT WOS 000555275600001 EID SCOPUS 85088860889 DOI 10.1111/mec.15539 Anotace Despite its inherent costs, sexual reproduction is ubiquitous in nature, and the mechanisms to protect it from a competitive displacement by asexuality remain unclear. Popular mutation-based explanations, like the Muller's ratchet and the Kondrashov's hatchet, assume that purifying selection may not halt the accumulation of deleterious mutations in the nonrecombining genomes, ultimately leading to their degeneration. However, empirical evidence is scarce and it remains particularly unclear whether mutational degradation proceeds fast enough to ensure the decay of clonal organisms and to prevent them from outcompeting their sexual counterparts. To test this hypothesis, we jointly analysed the exome sequences and the fitness-related phenotypic traits of the sexually reproducing fish species and their clonal hybrids, whose evolutionary ages ranged from F1 generations to 300 ky. As expected, mutations tended to accumulate in the clonal genomes in a time-dependent manner. However, contrary to the predictions, we found no trend towards increased nonsynonymity of mutations acquired by clones, nor higher radicality of their amino acid substitutions. Moreover, there was no evidence for fitness degeneration in the old clones compared with that in the younger ones. In summary, although an efficacy of purifying selection may still be reduced in the asexual genomes, our data indicate that its efficiency is not drastically decreased. Even the oldest investigated clone was found to be too young to suffer fitness consequences from a mutation accumulation. This suggests that mechanisms other than mutation accumulation may be needed to explain the competitive advantage of sex in the short term. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2021 Elektronická adresa https://onlinelibrary.wiley.com/doi/full/10.1111/mec.15539?af=R
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