Počet záznamů: 1
Developmental and sex differences in cardiac tolerance to ischemia-reperfusion injury: the role of mitochondria
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SYSNO ASEP 0508598 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Developmental and sex differences in cardiac tolerance to ischemia-reperfusion injury: the role of mitochondria Tvůrce(i) Ošťádal, Bohuslav (FGU-C) RID, ORCID
Drahota, Zdeněk (FGU-C) RID, ORCID
Houštěk, Josef (FGU-C) RID, ORCID
Milerová, Marie (FGU-C)
Ošťádalová, Ivana (FGU-C) RID
Hlaváčková, Markéta (FGU-C) RID, ORCID
Kolář, František (FGU-C) RID, ORCID, SAIZdroj.dok. Canadian Journal of Physiology and Pharmacology. - : Canadian Science Publishing - ISSN 0008-4212
Roč. 97, č. 9 (2019), s. 808-814Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. CA - Kanada Klíč. slova neonatal heart ; female heart ; ischemia-reperfusion injury ; cardiac ischemic tolerance ; mitochondrial permeability transition pore ; calcium-induced swelling Vědní obor RIV ED - Fyziologie Obor OECD Physiology (including cytology) CEP GA18-03461S GA ČR - Grantová agentura ČR GJ19-04790Y GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000483022200003 EID SCOPUS 85068336761 DOI 10.1139/cjpp-2019-0060 Anotace Age and sex play an essential role in the cardiac tolerance to ischemia-reperfusion injury: cardiac resistance significantly decreases during postnatal maturation and the female heart is more tolerant than the male myocardium. It is widely accepted that mitochondrial dysfunction, and particularly mitochondrial permeability transition pore (MPTP) opening, plays a major role in determining the extent of cardiac ischemia-reperfusion injury. We have observed that the MPTP sensitivity to the calcium load differs in mitochondria isolated from neonatal and adult myocardium, as well as from adult male and female hearts. Neonatal and female mitochondria are more resistant both in the extent and in the rate of mitochondrial swelling induced by high calcium concentration. Our data further suggest that age-and sex-dependent specificity of the MPTP is not the result of different amounts of ATP synthase and cyclophilin D: neonatal and adult hearts, similarly as the male and female hearts, contain comparable amounts of MPTP and its regulatory protein cyclophilin D. We can speculate that the lower sensitivity of MPTP to the calcium-induced swelling may be related to the higher ischemic tolerance of both neonatal and female myocardium. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2020 Elektronická adresa https://www.nrcresearchpress.com/doi/10.1139/cjpp-2019-0060#.XljPJKhKiUk
Počet záznamů: 1