Počet záznamů: 1
Cannabis-induced altered states of consciousness are associated with specific dynamic brain connectivity states
- 1.
SYSNO ASEP 0506880 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cannabis-induced altered states of consciousness are associated with specific dynamic brain connectivity states Tvůrce(i) Zaytseva, Y. (CZ)
Horáček, J. (CZ)
Hlinka, Jaroslav (UIVT-O) RID, SAI, ORCID
Fajnerová, I. (CZ)
Androvičová, R. (CZ)
Tintěra, J. (CZ)
Salvi, V. (IT)
Balíková, M. (CZ)
Hložek, T. (CZ)
Španiel, F. (CZ)
Páleníček, T. (CZ)Zdroj.dok. Journal of Psychopharmacology. - : Sage - ISSN 0269-8811
Roč. 33, č. 7 (2019), s. 811-821Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Cannabis ; tetrahydrocannabinol ; altered states of consciousness ; resting state networks ; dynamic functional connectivity Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology CEP GA17-01251S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UIVT-O - RVO:67985807 UT WOS 000472769400006 EID SCOPUS 85067854318 DOI 10.1177/0269881119849814 Anotace Background: Cannabis, and specifically one of its active compounds delta-9-tetrahydrocannabinol in recreational doses, has a variety of effects on cognitive processes. Most studies employ resting state functional magnetic resonance imaging techniques to assess the stationary effects of cannabis and to-date one report addressed the impact of delta-9-tetrahydrocannabinol on the dynamics of whole-brain functional connectivity. Methods: Using a repeated-measures, within-subjects design, 19 healthy occasional cannabis users (smoking cannabis <= 2 per week) underwent resting state functional magnetic resonance imaging scans. Each subject underwent two scans: in the intoxicated condition, shortly after smoking a cannabis cigarette, and in the non-intoxicated condition, with the subject being free from cannabinoids for at least one week before. All sessions were randomized and performed in a four-week interval. Data were analysed employing a standard independent component analysis approach with subsequent tracking of the functional connectivity dynamics, which allowed six connectivity clusters (states) to be individuated. Results: Using standard independent component analysis in resting state functional connectivity, a group effect was found in the precuneus connectivity. With a dynamic independent component analysis approach, we identified one transient connectivity state, characterized by high connectivity within and between auditory and somato-motor cortices and anti-correlation with subcortical structures and the cerebellum that was only found during the intoxicated condition. Behavioural measures of the subjective experiences of changed perceptions and tetrahydrocannabinol plasma levels during intoxication were associated with this state. Conclusions: With the help of the dynamic connectivity approach we could elucidate neural correlates of the transitory perceptual changes induced by delta-9-tetrahydrocannabinol in cannabis users, and possibly identify a biomarker of cannabis intoxication. Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2020 Elektronická adresa http://dx.doi.org/10.1177/0269881119849814
Počet záznamů: 1