Počet záznamů: 1
Lime is a new protein linking immunity and metabolism in Drosophila
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SYSNO ASEP 0506482 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Lime is a new protein linking immunity and metabolism in Drosophila Tvůrce(i) Mihajlović, Zorana (BC-A)
Tanasic, D. (CZ)
Bajgar, Adam (BC-A) RID
Perez-Gomez, Raquel (BC-A) RID, ORCID
Steffal, P. (CZ)
Krejčí, Alena (BC-A) RID, ORCIDCelkový počet autorů 6 Zdroj.dok. Developmental Biology. - : Elsevier - ISSN 0012-1606
Roč. 452, č. 2 (2019), s. 83-94Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova CG184446 ; Drosophila ; metabolism Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology CEP GA17-17529S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora BC-A - RVO:60077344 UT WOS 000473375100003 EID SCOPUS 85065762707 DOI 10.1016/j.ydbio.2019.05.005 Anotace The proliferation, differentiation and function of immune cells in vertebrates, as well as in the invertebrates, is regulated by distinct signalling pathways and crosstalk with systemic and cellular metabolism. We have identified the Lime gene (Linking Immunity and Metabolism, CG18446) as one such connecting factor, linking hemocyte development with systemic metabolism in Drosophila. Lime is expressed in larval plasmatocytes and the fat body and regulates immune cell type and number by influencing the size of hemocyte progenitor populations in the lymph gland and in circulation. Lime mutant larvae exhibit low levels of glycogen and trehalose energy reserves and they develop low number of hemocytes. The low number of hemocytes in Lime mutants can be rescued by Lime overexpression in the fat body. It is well known that immune cell metabolism is tightly regulated with the progress of infection and it must be supported by systemic metabolic changes. Here we demonstrate that Lime mutants fails to induce such systemic metabolic changes essential for the larval immune response. Indeed, Lime mutants are not able to sustain high numbers of circulating hemocytes and are compromised in the number of lamellocytes produced during immune system challenge, using a parasitic wasp infection model. We therefore propose the Lime gene as a novel functional link between systemic metabolism and Drosophila immunity. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2020 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0012160618305815?via%3Dihub
Počet záznamů: 1