Počet záznamů: 1
Diagnosis of Pancreatic Cancer via 1H NMR Metabolomics of Human Plasma.
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SYSNO ASEP 0497576 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Diagnosis of Pancreatic Cancer via 1H NMR Metabolomics of Human Plasma. Tvůrce(i) Michálková, Lenka (UCHP-M) RID, ORCID, SAI
Horník, Štěpán (UCHP-M) ORCID, RID, SAI
Sýkora, Jan (UCHP-M) RID, ORCID, SAI
Habartová, L. (CZ)
Setnička, V. (CZ)Zdroj.dok. Analyst. - : Royal Society of Chemistry - ISSN 0003-2654
Roč. 143, č. 24 (2018), s. 5974-5978Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova NMR metabolomics ; pancreatic cancer Vědní obor RIV CB - Analytická chemie, separace Obor OECD Analytical chemistry Institucionální podpora UCHP-M - RVO:67985858 UT WOS 000452110500010 EID SCOPUS 85057754693 DOI 10.1039/c8an01310a Anotace Metabolic changes induced by pancreatic cancer were investigated by 1H NMR spectroscopy of plasma samples of patients and healthy controls. The acquired data were submitted to multivariate statistical analysis providing clear discrimination between both groups. The most significant differences were found in levels of 3-hydroxybutyrate and lactate. The obtained results (100% sensitivity, 90% specificity) clearly show the potential of 1H NMR spectroscopy in pancreatic cancer diagnosis. Therefore, the NMR-based metabolomics may contribute to the early diagnosis, prevention and/or therapy of diseases in the future. On the other hand, the number of samples in the presented pilot study is limited and has to be significantly increased in the future in order to obtain solid statistical models and to confirm the current findings. Pracoviště Ústav chemických procesů Kontakt Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Rok sběru 2019
Počet záznamů: 1