Molecular-level control of ciclopirox olamine release from poly(ethylene oxide)-based mucoadhesive buccal films: exploration of structure–property relationships with solid-state NMR

Urbanová, Martina; Gajdosova, M.; Steinhart, Miloš; Vetchy, D.; Brus, Jiří

doi:https://dx.doi.org/10.1021/acs.molpharmaceut.6b00035

Počet záznamů: 1

Molecular-level control of ciclopirox olamine release from poly(ethylene oxide)-based mucoadhesive buccal films: exploration of structure–property relationships with solid-state NMR

1.

SYSNO ASEP	0459119
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Molecular-level control of ciclopirox olamine release from poly(ethylene oxide)-based mucoadhesive buccal films: exploration of structure–property relationships with solid-state NMR
Tvůrce(i)	Urbanová, Martina (UMCH-V)_{RID, ORCID} Gajdosova, M. (CZ) Steinhart, Miloš (UMCH-V)_RID Vetchy, D. (CZ) Brus, Jiří (UMCH-V)_{RID, ORCID}
Zdroj.dok.	Molecular Pharmaceutics. - : American Chemical Society - ISSN 1543-8384 Roč. 13, č. 5 (2016), s. 1551-1563
Poč.str.	13 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	mucoadhesive buccal films ; ciclopirox olamine ; PEO
Vědní obor RIV	CD - Makromolekulární chemie
CEP	GA14-03636S GA ČR - Grantová agentura ČR
	LO1507 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Institucionální podpora	UMCH-V - RVO:61389013
UT WOS	000375519600012
EID SCOPUS	84968677705
DOI	10.1021/acs.molpharmaceut.6b00035
Anotace	Mucoadhesive buccal films (MBFs) provide an innovative way to facilitate the efficient site-specific delivery of active compounds while simultaneously separating the lesions from the environment of the oral cavity. The structural diversity of these complex multicomponent and mostly multiphase systems as well as an experimental strategy for their structural characterization at molecular scale with atomic resolution were demonstrated using MBFs of ciclopirox olamine (CPX) in a poly(ethylene oxide) (PEO) matrix as a case study. A detailed description of each component of the CPX/PEO films was followed by an analysis of the relationships between each component and the physicochemical properties of the MBFs.
Pracoviště	Ústav makromolekulární chemie
Kontakt	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Rok sběru	2017

Počet záznamů: 1