Markers of Oxidative Stress and Inflammation Are More Elevated in the Exhaled Breath Condensate of Workers Exposed to nano-TiO2 than to nano-Fe Oxide Particles

0449589 - ÚCHP 2016 RIV US eng C - Konferenční příspěvek (zahraniční konf.)
Pelclová, D. - Zacharov, S. - Ždímal, Vladimír - Fenclová, Z. - Vlčková, Š. - Syslová, K. - Kuzma, Marek - Navrátil, Tomáš - Komarc, M. - Kačer, P.
Markers of Oxidative Stress and Inflammation Are More Elevated in the Exhaled Breath Condensate of Workers Exposed to nano-TiO2 than to nano-Fe Oxide Particles.
1556-3650. In: Clinical Toxicology, Volume 53, Issue 4. New York: INFORMA HEALTHCARE, 2015, 297-298, s. 297-298. ISSN 1556-3650. E-ISSN 1556-9519.
[International Congress of the European Association of Poisons Centres and Clinical Toxicologists /35./. Malta (MT), 26.09.2015-29.09.2015]
Institucionální podpora: RVO:67985858 ; RVO:61388955 ; RVO:61388971
Klíčová slova: occupational * biomonitoring * nanoparticles
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
http://www.tandfonline.com/doi/pdf/10.3109/15563650.2015.1024953

This study suggests adverse effects of exposure to aerosols containing a high proportion of nanoparticles of TiO 2 and Fe oxides with signs of inflammation and genotoxic/carcinogenic effect due to the oxidation of nucleic acids. As TiO2 and Fe oxides are of low toxicity, the effects may be attributed to the nanopar- ticles. The diameter of inhaled particles seems more important than the chemical composition, because nano-sized particles are able to cross cell membranes, unlike chemically identically bulk TiO2 and Fe oxides. As the non-soluble particles are removed from the lungs with a very long half-life, EBC appears a preferred biological fluid for the evaluation of their deleterious effect.
Trvalý link: http://hdl.handle.net/11104/0251130