Normuramyl glycopeptide compounds

0436025 - ÚOCHB 2015 RIV eng P - Patentový dokument
Hipler, K. - Miller, A. - Turánek, J. - Ledvina, Miroslav
Normuramyl glycopeptide compounds.
2014. Vlastník: Imuthes Limited - Ústav organické chemie a biochemie AV ČR, v. v. i. - Výzkumný ústav veterinárního lékařství, v. v. i. Datum udělení patentu: 18.02.2014. Číslo patentu: US8653049
Institucionální podpora: RVO:61388963
Klíčová slova: normuramyl * glycopeptide compounds
Obor OECD: Organic chemistry
http://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=8653049B2&KC=B2&FT=D&ND=4&date=20140218&DB=EPODOC&locale=en_EP

The invention provides a compound (which can act as an adjuvant) of Formula I or Formula (II), wherein R1 R4 R5 R6 and R7 are each independently selected from hydrogen, acetyl, hydrocarbyl, a lipid moiety and a lipid acyl moiety; R2 is a hydroxyl, a hydrocarbyl, a lipid moiety, a lipid acyl moiety; or an amino hydrocarbyl group optionally substituted with a hydrocarbyl, a lipid moiety or a lipid acyl moiety; R3 and R8 are each independently selected from acetyl, a hydrocarbyl, a lipid moiety and a lipid acyl moiety; X is a peptide chain; The above normuramylglycopeptide compounds can be located in liposomes and micelles and can function as immunomodulators, along with a desired antigen (or DNA encloding the antigen), in (e.g. DNA) vaccines.
Trvalý link: http://hdl.handle.net/11104/0239850