Počet záznamů: 1
Exploiting end group functionalization for the design of antifouling bioactive brushes
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SYSNO ASEP 0428662 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Exploiting end group functionalization for the design of antifouling bioactive brushes Tvůrce(i) Kuzmyn, Andrii (UMCH-V)
de los Santos Pereira, Andres (UMCH-V) RID, ORCID
Pop-Georgievski, Ognen (UMCH-V) RID, ORCID
Bruns, M. (DE)
Brynda, Eduard (UMCH-V) RID
Rodriguez-Emmenegger, Cesar (UMCH-V) RIDZdroj.dok. Polymer Chemistry . - : Royal Society of Chemistry - ISSN 1759-9954
Roč. 5, č. 13 (2014), s. 4124-4131Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova click chemistry ; end-group functionalization ; non-fouling Vědní obor RIV CD - Makromolekulární chemie CEP GAP205/12/1702 GA ČR - Grantová agentura ČR GAP108/11/1857 GA ČR - Grantová agentura ČR ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000337097500023 EID SCOPUS 84901829747 DOI 10.1039/C4PY00281D Anotace Biologically active surfaces are essential in many applications in the fields of biosensing, bioimplants, and tissue engineering. However, the introduction of bioactive motifs without impairment of their ability to resist non-specific interactions with biological media remains a challenge. Herein, we present a straightforward, facile strategy for the creation of bioactive surfaces based on the end-group biofunctionalization of state-of-the-art polymer brushes via an ultra-fast Diels–Alder “click” reaction. Surface-initiated atom transfer radical polymerization is employed to grow antifouling polymers preserving the end groups. These groups are then further converted to a reactive cyclopentadienyl moiety and exploited for the immobilization of biomolecules on the topmost layer of the brush. The minimal chemical modification of the antifouling polymer brush accounts for the full preservation of the fouling resistance of the surface even after biofunctionalization, which is critical for the aforementioned applications. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2015
Počet záznamů: 1