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Deletion of protease-activated receptor 2 prolongs survival of scrapie-inoculated mice
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SYSNO ASEP 0389996 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Deletion of protease-activated receptor 2 prolongs survival of scrapie-inoculated mice Tvůrce(i) Matěj, R. (CZ)
Olejár, Tomáš (FGU-C) RID
Janoušková, O. (CZ)
Holada, K. (CZ)Zdroj.dok. Journal of General Virology. - : Microbiology Society - ISSN 0022-1317
Roč. 93, č. 9 (2012), s. 2057-2061Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova protease-activated receptor (PAR2) ; scrapie ; neurodegenerative disorders Vědní obor RIV FN - Epidemiologie, infek. nemoci a klin. imunologie Institucionální podpora FGU-C - RVO:67985823 UT WOS 000309035100025 DOI 10.1099/vir.0.043877-0 Anotace Proteinase-activated receptor 2 (PAR2) has recently been identified to be a possible modulator of neurodegeneration. To investigate whether PAR2 plays a role in prion infection, we inoculated PAR2-deficient (PAR2/) and wild-type (WT) mice intracerebrally with the Rocky Mountain Laboratory strain of scrapie. PAR2/ mice demonstrated a delayed onset of clinical symptoms, including weight loss, and demonstrated moderate but highly significant prolongation of survival over WT controls. Concomitantly, no apparent differences in brain pathology, infectivity or features of brain prion protein between deceased WT and PAR2/mice were found. Our study suggests that PAR2 deletion modulates dynamics of the disease without gross perturbation of its pathogenesis Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2013
Počet záznamů: 1