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Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer
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SYSNO ASEP 0384590 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer Tvůrce(i) Green, N. K. (GB)
Hale, A. (GB)
Cawood, R. (GB)
Illingworth, S. (GB)
Herbert, C. (GB)
Hermiston, T. (US)
Šubr, Vladimír (UMCH-V) RID, ORCID
Ulbrich, Karel (UMCH-V) RID
van Rooijen, N. (NL)
Seymour, L. W. (GB)
Fisher, K. D. (GB)Zdroj.dok. Nanomedicine. - : Future Medicine - ISSN 1743-5889
Roč. 7, č. 11 (2012), s. 1683-1695Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova clodronate liposomes ; polymer-coated adenovirus ; predosing strategy Vědní obor RIV CD - Makromolekulární chemie CEP IAAX00500803 GA AV ČR - Akademie věd Institucionální podpora UMCH-V - RVO:61389013 CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000311329700013 DOI 10.2217/NNM.12.50 Anotace Intravenous delivery of therapeutic virus particles remains a major goal for virotherapy of metastatic cancer. Polymer coating of adenovirus type 5 (Ad5) can combine with predosing strategies or Kupffer cell ablation to achieve systemic kinetics with a half-life >60 min, allowing ready access to peripheral tumors. Polymer coating wild-type Ad5 in this way is known to decrease hepatic toxicity, increasing the dose of virus particles that can be safely administered. Using polymer-coating technology to deliver a replicating Ad5 systemically, virus replication and transgene expression was almost totally confined to tumor tissues, giving a much improved therapeutic index compared with uncoated virus, and complete control of human HepG2 tumor xenografts. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2013
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