Inhibition of the antibody responses to rat blood transfusion antigens in mice by boar seminal immunosuppressive fraction

0191169 - UMG-J 20010238 RIV DK eng J - Článek v odborném periodiku
Veselský, Leopold - Jonáková, Věra - Dostál, Jaromír - Holáň, Vladimír - Voburka, Zdeněk - Drahorád, Josef - Maňásková, Pavla - Železná, Blanka
Inhibition of the antibody responses to rat blood transfusion antigens in mice by boar seminal immunosuppressive fraction.
American Journal of Reproductive Immunology and Microbiology. Roč. 44, č. 6 (2000), s. 325-335. ISSN 8755-8920
Grant CEP: GA ČR GA204/98/0827; GA ČR GV524/96/K162; GA ČR GA303/99/0357; GA MZd NC4534
Výzkumný záměr: CEZ:AV0Z5052915
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 1.932, rok: 2000

ISF and H^- fraction were proved to be equal complexes of porcine seminal plasma (PSP) proteins PSP I and PSP II. Both inhibited antibody responses to rat erythrocytes and serum and the concentrations of IgM, IgG, IgG₁ and IgG₂ after the first transfusion with a long-lasting effect. Both suppressed the secondary antibody production if applied before the second transfusion. IgA and IgG₃ stayed uninfluenced. ISF and H^- fraction had an equal immunosuppressive effect. ISF was determined to be powerful in overcoming unwanted antibody responses to xenotransfusion
Trvalý link: http://hdl.handle.net/11104/0086926