Bioconjugates of cathepsin K inhibitors with water/soluble polymers: potential drugs for the treatment of osteoporosis and rheumatoid arthritis

0188725 - UMCH-V 20023337 RIV TR eng C - Konferenční příspěvek (zahraniční konf.)
Wang, D. - Pechar, Michal - Kopečková, P. - Brömme, D. - Kopeček, J.
Bioconjugates of cathepsin K inhibitors with water/soluble polymers: potential drugs for the treatment of osteoporosis and rheumatoid arthritis.
Intelligent Drug Delivery Systems Better and Safer Therapy. Istanbul: Hacettepe University Pharmacy Faculty, 2002, s. 12-13. ISBN 975-491-126-6.
[International Pharmaceutical Technology Symposium /11./ Intelligent Drug Delivery Systems Better and Safer Therapy. Istanbul (TR), 09.09.2002-11.09.2002]
Grant CEP: GA AV ČR KSK4055109
Klíčová slova: Cathepsin K
Kód oboru RIV: CE - Biochemie

We synthesized novel bioconjugates of cathepsin K inhibitor, 1-(N-benzyl-oxy-carbonylleucyl)-5-(phenylalanylleucyl)-carbo-hydrazide with a-methoxy poly(ethylene glycol), semitelechelic poly[N-(2-hydroxypropyl)-methacrylamide] and HPMA copolymers containing reactive side-chans. The inhibitory activity of macromolecular inhibitors for cysteine proteinases as well as their ability to inhibit cathepsin K activity in synovial fibroblasts were evaluated.
Trvalý link: http://hdl.handle.net/11104/0084635