Allelic and haplotype frequencies of the p53 polymorphisms in brain tumor patients
1.
SYSNO ASEP
0173578
Druh ASEP
J - Článek v odborném periodiku
Zařazení RIV
J - Článek v odborném periodiku
Poddruh J
Ostatní články
Název
Allelic and haplotype frequencies of the p53 polymorphisms in brain tumor patients
Tvůrce(i)
Biroš, Erik (UEM-P) Kalina, I. (SK) Kohút, A. (SK) Bogyiová, E. (SK) Šalagovič, J. (SK) Šulla, I. (SK)
Zdroj.dok.
Physiological Research. - : Fyziologický ústav AV ČR, v. v. i.
- ISSN 0862-8408
Roč. 51, č. 1 (2002), s. 59-64
Poč.str.
6 s.
Jazyk dok.
eng - angličtina
Země vyd.
CZ - Česká republika
Klíč. slova
Brain tumor ; Susceptibility ; p53
Vědní obor RIV
FD - Onkologie a hematologie
CEP
SI/340/1/97 GA MŽP - Ministerstvo životního prostředí
CEZ
AV0Z5039906 - UEM-P
Anotace
The polymorphisms of the tumor suppressor gene p53 in exon 4 (p53 BstUI) and in intron 6 (p53 MspI) have been suggested to be associated with the genetically determined susceptibility in diverse types of human cancer. In our hospital-based case-control study, we examined the allele and genotype incidence of these polymorphisms as well as their haplotype combinations in 60 brain tumor patients (27 males and 33 females) and 183 controls without malignancies. The genotype characteristics were determined by the PCR-based RFLP method using DNA extracted from peripheral blood. In this study we show that the p53 BstUI and the p53 MspI polymorphisms are not associated with increased risk of brain tumors. Thus, we conclude that the p53 BstUI and the p53 MspI polymorphic sites within the tumor suppressor gene p53 do not represent genetic determinants of susceptibility to brain tumors.
