Počet záznamů: 1
Iron-based compounds coordinated with phospho-polymers as biocompatible probes for dual 31P/1H magnetic resonance imaging and spectroscopy
- 1.
SYSNO ASEP 0583057 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Iron-based compounds coordinated with phospho-polymers as biocompatible probes for dual 31P/1H magnetic resonance imaging and spectroscopy Tvůrce(i) Kracíková, Lucie (UMCH-V) ORCID
Androvič, Ladislav (UMCH-V) ORCID
Červený, D. (CZ)
Jirát-Ziólkowska, N. (CZ)
Babič, Michal (UMCH-V) RID, ORCID
Švábová, Monika (UMCH-V) RID, ORCID
Jirák, D. (CZ)
Laga, Richard (UMCH-V) RID, ORCIDČíslo článku 3847 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 14, č. 1 (2024)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova phospho-polymers ; maghemite nanoparticles ; iron chelation Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP NU20-08-00095 GA MZd - Ministerstvo zdravotnictví Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 001163476700030 EID SCOPUS 85185243925 DOI 10.1038/s41598-024-54158-x Anotace In this work, we present the synthesis and evaluation of magnetic resonance (MR) properties of novel phosphorus/iron-containing probes for dual 31P and 1H MR imaging and spectroscopy (MRI and MRS). The presented probes are composed of biocompatible semitelechelic and multivalent phospho-polymers based on poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC) coordinated with small paramagnetic Fe3+ ions or superparamagnetic maghemite (γ-Fe2O3) nanoparticles via deferoxamine group linked to the end or along the polymer chains. All probes provided very short 1H T1 and T2 relaxation times even at low iron concentrations. The presence of iron had a significant impact on the shortening of 31P relaxation, with the effect being more pronounced for probes based on γ-Fe2O3 and multivalent polymer. While the water-soluble probe having one Fe3+ ion per polymer chain was satisfactorily visualized by both 31P-MRS and 31P-MRI, the probe with multiple Fe3+ ions could only be detected by 31P-MRS, and the probes consisting of γ-Fe2O3 nanoparticles could not be imaged by either technique due to their ultra-short 31P relaxations. In this proof-of-principle study performed on phantoms at a clinically relevant magnetic fields, we demonstrated how the different forms and concentrations of iron affect both the 1H MR signal of the surrounding water molecules and the 31P MR signal of the phospho-polymer probe. Thus, this double contrast can be exploited to simultaneously visualize body anatomy and monitor probe biodistribution. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2025 Elektronická adresa https://www.nature.com/articles/s41598-024-54158-x
Počet záznamů: 1