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Serum biomarkers of hypoxic-ischemic brain injury
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SYSNO ASEP 0580552 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Serum biomarkers of hypoxic-ischemic brain injury Tvůrce(i) Tefr Faridová, A. (CZ)
Heřman, H. (CZ)
Danačíková, Šárka (FGU-C) ORCID
Svoboda, Jan (FGU-C)
Otáhal, Jakub (FGU-C) RID, ORCID, SAIZdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 72, Suppl.5 (2023), S461-S474Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova brain injury ; serum biomarkers ; neuron-specific enolase ; ubiquitin carboxy-terminal hydrolase L1 ; S100 calcium-binding protein beta ; glial fibrillary acidic protein ; high-mobility-groupprotein-box-1 Obor OECD Neurosciences (including psychophysiology CEP LX22NPO5107 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 001198072000003 EID SCOPUS 85181773001 DOI 10.33549/physiolres.935214 Anotace Brain injury is a multifaceted condition arising from nonspecific damage to nervous tissue. The resulting cognitive developmental impairments reverberate through patients' lives, affecting their families, and even the broader economic landscape. The significance of early brain injury detection lies in its potential to stave off severe consequences and enhance the effectiveness of tailored therapeutic interventions. While established methods like neuroimaging and neurophysiology serve as valuable diagnostic tools, their demanding nature restricts their accessibility, particularly in scenarios such as small hospitals, nocturnal or weekend shifts, and cases involving unstable patients. Hence, there is a pressing need for more accessible and efficient diagnostic avenues. Among the spectrum of brain injuries, hypoxic-ischemic encephalopathy stands out as a predominant affliction in the pediatric population. Diagnosing brain injuries in newborns presents challenges due to the subjective nature of assessments like Apgar scores and the inherent uncertainty in neurological examinations. In this context, methods like magnetic resonance and ultrasound hold recommendations for more accurate diagnosis. Recognizing the potential of serum biomarkers derived from blood samples, this paper underscores their promise as a more expedient and resource-efficient means of assessing brain injuries. The review compiles current insights into serum biomarkers, drawing from experiments conducted on animal models as well as human brain pathologies. The authors aim to elucidate specific characteristics, temporal profiles, and the available corpus of experimental and clinical data for serum biomarkers specific to brain injuries. These include neuronspecific enolase (NSE), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), S100 calcium-binding protein beta (S100B), glial fibrillary acidic protein (GFAP), and high-mobility-group-proteinbox-1 (HMGB1). This comprehensive endeavor contributes to advancing the understanding of brain injury diagnostics and potential avenues for therapeutic intervention. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2024 Elektronická adresa https://www.biomed.cas.cz/physiolres/pdf/72/72_S461.pdf
Počet záznamů: 1