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Microbiota as the unifying factor behind the hallmarks of cancer
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SYSNO ASEP 0578527 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Microbiota as the unifying factor behind the hallmarks of cancer Tvůrce(i) Benešová, Iva (MBU-M)
Křížová, L. (CZ)
Kverka, Miloslav (MBU-M) RID, ORCIDCelkový počet autorů 3 Zdroj.dok. Journal of Cancer Research and Clinical Oncology - ISSN 0171-5216
Roč. 149, č. 15 (2023), s. 14429-14450Poč.str. 22 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova regulatory t-cells ; gut microbiota ; fusobacterium-nucleatum ; colorectal-cancer ; intestinal microbiota ; commensal bacteria ; helicobacter-pylori ; therapy efficacy ; up-regulation ; tumor-growth ; Gut microbiota ; Hallmarks of cancer ; Tumor microenvironment ; Fecal microbiota transplantation Obor OECD Oncology CEP NV19-03-00179 GA MZd - Ministerstvo zdravotnictví Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 001044879000002 EID SCOPUS 85167368641 DOI 10.1007/s00432-023-05244-6 Anotace The human microbiota is a complex ecosystem that colonizes body surfaces and interacts with host organ systems, especially the immune system. Since the composition of this ecosystem depends on a variety of internal and external factors, each individual harbors a unique set of microbes. These differences in microbiota composition make individuals either more or less susceptible to various diseases, including cancer. Specific microbes are associated with cancer etiology and pathogenesis and several mechanisms of how they drive the typical hallmarks of cancer were recently identified. Although most microbes reside in the distal gut, they can influence cancer initiation and progression in distant tissues, as well as modulate the outcomes of established cancer therapies. Here, we describe the mechanisms by which microbes influence carcinogenesis and discuss their current and potential future applications in cancer diagnostics and management. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2024 Elektronická adresa https://link.springer.com/article/10.1007/s00432-023-05244-6
Počet záznamů: 1