Počet záznamů: 1
Mitochondria on the move: Horizontal mitochondrial transfer in disease and health
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SYSNO ASEP 0571547 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Mitochondria on the move: Horizontal mitochondrial transfer in disease and health Tvůrce(i) Dong, L. (AU)
Rohlena, Jakub (BTO-N) RID, ORCID
Zobalová, Renata (BTO-N) RID
Nahácka, Zuzana (BTO-N)
Rodriguez, A. (FR)
Berridge, M. V. V. (NZ)
Neužil, Jiří (BTO-N) RIDCelkový počet autorů 7 Číslo článku e202211044 Zdroj.dok. Journal of Cell Biology. - : Rockefeller University Press - ISSN 0021-9525
Roč. 222, č. 3 (2023)Poč.str. 27 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova MESENCHYMAL STEM-CELLS ; MULTIPOTENT STROMAL CELLS ; TUNNELING NANOTUBES Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Cell biology CEP GA20-05942S GA ČR - Grantová agentura ČR GX21-04607X GA ČR - Grantová agentura ČR GA22-34507S GA ČR - Grantová agentura ČR GA22-34507S GA ČR - Grantová agentura ČR NU22-08-00160 GA MZd - Ministerstvo zdravotnictví Způsob publikování Open access Institucionální podpora BTO-N - RVO:86652036 UT WOS 000944268100001 EID SCOPUS 85148259890 DOI 10.1083/jcb.202211044 Anotace Jiri Neuzil and colleagues review the processes and mechanisms that underlie horizontal mitochondrial transfer (HMT) and the metabolic consequences of HMT in cells. Mammalian genes were long thought to be constrained within somatic cells in most cell types. This concept was challenged recently when cellular organelles including mitochondria were shown to move between mammalian cells in culture via cytoplasmic bridges. Recent research in animals indicates transfer of mitochondria in cancer and during lung injury in vivo, with considerable functional consequences. Since these pioneering discoveries, many studies have confirmed horizontal mitochondrial transfer (HMT) in vivo, and its functional characteristics and consequences have been described. Additional support for this phenomenon has come from phylogenetic studies. Apparently, mitochondrial trafficking between cells occurs more frequently than previously thought and contributes to diverse processes including bioenergetic crosstalk and homeostasis, disease treatment and recovery, and development of resistance to cancer therapy. Here we highlight current knowledge of HMT between cells, focusing primarily on in vivo systems, and contend that this process is not only (patho)physiologically relevant, but also can be exploited for the design of novel therapeutic approaches. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2024 Elektronická adresa https://rupress.org/jcb/article/222/3/e202211044/213873/Mitochondria-on-the-move-Horizontal-mitochondrial
Počet záznamů: 1