Počet záznamů: 1
Diverse susceptibilities and responses of human and rodent cells to orthohantavirus infection reveal different levels of cellular restriction
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SYSNO ASEP 0569585 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Diverse susceptibilities and responses of human and rodent cells to orthohantavirus infection reveal different levels of cellular restriction Tvůrce(i) Gallo, G. (FR)
Kotlík, Petr (UZFG-Y) RID, ORCID
Roingeard, P. (FR)
Monot, M. (FR)
Chevreux, G. (FR)
Ulrich, R. G. (DE)
Tordo, N. (FR)
Ermonval, M. (FR)Číslo článku e0010844 Zdroj.dok. PLoS Neglected Tropical Diseases. - : Public Library of Science - ISSN 1935-2735
Roč. 16, č. 10 (2022)Poč.str. 41 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova rodent ; orthohantavirus Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology Způsob publikování Open access Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 000922587500058 EID SCOPUS 85140658520 DOI 10.1371/journal.pntd.0010844 Anotace Orthohantaviruses are zoonotic RNA viruses found all over the world in association with small mammal reservoirs. When occasionally transmitted to humans by aerosol they can cause two main types of diseases: hemorrhagic fever with renal syndrome (HFRS) mainly in Europe and Asia and hantavirus cardiopulmonary syndrome (HCPS) in North and South America with a case fatality rate of up to 15% and 40% respectively. An increasing number of outbreaks are recorded in endemic areas and, with disturbance of rodent habitats, climate change and the risk of virus genome reassortment, the emergence of new orthohantaviruses is of concern. With no treatment, no vaccines and few molecular tools, little is known about the pathophysiology of these viruses. Our comparative study of the viral cycle and interaction of different pathogenic and low or non-pathogenic orthohantaviruses in cells derived from human or rodent hosts reveals differences in entry, RNA replication or release of infectious particles, concurrently to regulation of host genes. This study illustrates how the development of a rodent host cell model together with the availability of an annotated bank vole genome may contribute to a better understanding of mechanisms of the interactions between orthohantaviruses and their hosts. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2023 Elektronická adresa https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010844
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