Počet záznamů: 1
Dynamic Evolution of Avian RNA Virus Sensors: Repeated Loss of RIG-I and RIPLET
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SYSNO ASEP 0567288 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Dynamic Evolution of Avian RNA Virus Sensors: Repeated Loss of RIG-I and RIPLET Tvůrce(i) Krchlíková, Veronika (UMG-J)
Hron, Tomáš (UMG-J)
Těšický, M. (CZ)
Li, T. (CZ)
Ungrová, Lenka (UMG-J)
Hejnar, Jiří (UMG-J) RID
Vinkler, M. (CZ)
Elleder, Daniel (UMG-J) RIDČíslo článku 3 Zdroj.dok. Viruses. - : MDPI
Roč. 15, č. 1 (2023)Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova avian genome ; viral sensors ; innate immunity ; gene loss Obor OECD Immunology CEP LX22NPO5103 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA20-22063S GA ČR - Grantová agentura ČR Výzkumná infrastruktura e-INFRA CZ - 90140 - CESNET, zájmové sdružení právnických osob Způsob publikování Open access Institucionální podpora UMG-J - RVO:68378050 UT WOS 000927117600001 EID SCOPUS 85146768734 DOI 10.3390/v15010003 Anotace Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) are key RNA virus sensors belonging to the RIG-I-like receptor (RLR) family. The activation of the RLR inflammasome leads to the establishment of antiviral state, mainly through interferon-mediated signaling. The evolutionary dynamics of RLRs has been studied mainly in mammals, where rare cases of RLR gene losses were described. By in silico screening of avian genomes, we previously described two independent disruptions of MDA5 in two bird orders. Here, we extend this analysis to approximately 150 avian genomes and report 16 independent evolutionary events of RIG-I inactivation. Interestingly, in almost all cases, these inactivations are coupled with genetic disruptions of RIPLET/RNF135, an ubiquitin ligase RIG-I regulator. Complete absence of any detectable RIG-I sequences is unique to several galliform species, including the domestic chicken (Gallus gallus). We further aimed to determine compensatory evolution of MDA5 in RIG-I-deficient species. While we were unable to show any specific global pattern of adaptive evolution in RIG-I-deficient species, in galliforms, the analyses of positive selection and surface charge distribution support the hypothesis of some compensatory evolution in MDA5 after RIG-I loss. This work highlights the dynamic nature of evolution in bird RNA virus sensors. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2024 Elektronická adresa https://www.mdpi.com/1999-4915/15/1/3
Počet záznamů: 1