Počet záznamů: 1
Oxidative Stress and Antioxidant Response in Populations of the Czech Republic Exposed to Various Levels of Environmental Pollutants
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SYSNO ASEP 0567217 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Oxidative Stress and Antioxidant Response in Populations of the Czech Republic Exposed to Various Levels of Environmental Pollutants Tvůrce(i) Ambrož, Antonín (UEM-P)
Rössner ml., Pavel (UEM-P) RID, ORCID
Rössnerová, Andrea (UEM-P) RID
Hoňková, Kateřina (UEM-P)
Milcová, Alena (UEM-P)
Pastorková, Anna (UEM-P) RID
Kléma, J. (CZ)
Pulkrabová, J. (CZ)
Pařízek, O. (CZ)
Vondrašková, V. (CZ)
Zelenka, J. (CZ)
Vrzáčková, N. (CZ)
Schmuczerová, J. (CZ)
Topinka, Jan (UEM-P) RID, ORCID
Šrám, Radim (UEM-P) RIDČíslo článku 3609 Zdroj.dok. International Journal of Environmental Research and Public Health. - : MDPI - ISSN 1661-7827
Roč. 19, č. 6 (2022)Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova oxidative damage ; DNA ; lipids ; antioxidant response ; environmental factors ; POPs Obor OECD Public and environmental health CEP LM2018124 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LM2018133 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy EF16_013/0001821 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy EF16_019/0000798 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 000775244200001 EID SCOPUS 85126484916 DOI 10.3390/ijerph19063609 Anotace We aimed to identify the variables that modify levels of oxidatively damaged DNA and lipid peroxidation in subjects living in diverse localities of the Czech Republic (a rural area, a metropolitan locality, and an industrial region). The sampling of a total of 126 policemen was conducted twice in two sampling seasons. Personal characteristics, concentrations of particulate matter of aerodynamic diameter <2.5 mu m and benzo[a]pyrene in the ambient air, activities of antioxidant mechanisms (superoxide dismutase, catalase, glutathione peroxidase, and antioxidant capacity), levels of pro-inflammatory cytokines (TNF-alpha, IL-1 beta, and IL-6), concentrations of persistent organic pollutants in blood plasma, and urinary levels of polycyclic aromatic hydrocarbon metabolites were investigated as parameters potentially affecting the markers of DNA oxidation (8-oxo-7,8-dihydro-2 -deoxyguanosine) and lipid peroxidation (15-F2t-isoprostane). The levels of oxidative stress markers mostly differed between the localities in the individual sampling seasons. Multivariate linear regression analysis revealed IL-6, a pro-inflammatory cytokine, as a factor with the most pronounced effects on oxidative stress parameters. The role of other variables, including environmental pollutants, was minor. In conclusion, our study showed that oxidative damage to macromolecules was affected by processes related to inflammation, however, we did not identify a specific environmental factor responsible for the pro-inflammatory response in the organism. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2023 Elektronická adresa https://www.mdpi.com/1660-4601/19/6/3609
Počet záznamů: 1