Počet záznamů: 1
Administration of nitro-oleic acid mitigates radiation-induced hematopoietic injury in mice
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SYSNO ASEP 0564730 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Administration of nitro-oleic acid mitigates radiation-induced hematopoietic injury in mice Tvůrce(i) Perečko, Tomáš (BFU-R) RID, ORCID
Hoferová, Zuzana (BFU-R) RID
Hofer, Michal (BFU-R) RID, ORCID
Perečková, Jana (BFU-R) ORCID
Falk, Martin (BFU-R) RID, ORCIDCelkový počet autorů 5 Číslo článku 121106 Zdroj.dok. Life Sciences. - : Elsevier - ISSN 0024-3205
Roč. 310, DEC 1 2022 (2022)Poč.str. 9 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Acute radiation syndrome ; Bone marrow cells ; Hematopoiesis ; g-csf ; Nitrooleic acid Vědní obor RIV FR - Farmakologie a lékárnická chemie Obor OECD Pharmacology and pharmacy CEP GA19-09212S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora BFU-R - RVO:68081707 UT WOS 000880317300001 EID SCOPUS 85140399032 DOI 10.1016/j.lfs.2022.121106 Anotace Aims: Limited number of agents that provide protection against hematopoietic acute radiation syndrome led us to the evaluation of nitro-oleic acid (NO(2)OA) as a potential protector/mitigator against radiation-induced hematopoietic injury in C57/BL6 mice. Materials and methods: NO(2)OA was administered before and after sub-lethal total body irradiation (TBI) and hematological parameters were evaluated 3 or 7 days after TBI. Key findings: Our results show that NO(2)OA significantly increase bone marrow cellularity including the granulocyte-macrophage colony-forming cells and erythroid progenitors on the 3rd day after TBI. In addition, NO(2)OA enhanced recovery of white blood cells (lymphocytes, neutrophils, and monocytes) in peripheral blood 7 days after irradiation. These effects may be in part attributed to NO(2)OA-induced granulocyte colony-stimulating factor production after TBI. On the other hand, radiation-induced impairment of peripheral red blood cells, hemoglobin, and platelets were not affected with NO(2)OA treatment up to 7 days post TBI. Significance: In conclusion, our data show that NO(2)OA significantly protects hematopoiesis after irradiation, and thus showed a high potential to act as an agent for medical radiation countermeasure. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2023 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0024320522008062?via%3Dihub
Počet záznamů: 1