Počet záznamů: 1
Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection
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SYSNO ASEP 0554894 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection Tvůrce(i) Bohalova, Natalia (BFU-R) ORCID
Cantara, Alessio (BFU-R)
Bartas, M. (CZ)
Kaura, P. (CZ)
Šťastný, J. (CZ)
Pečinka, P. (CZ)
Fojta, Miroslav (BFU-R) RID, ORCID
Mergny, Jean-Louis (BFU-R) ORCID, RID
Brázda, Václav (BFU-R) RID, ORCIDCelkový počet autorů 9 Zdroj.dok. Biochimie. - : Elsevier - ISSN 0300-9084
Roč. 186, JUL 2021 (2021), s. 13-27Poč.str. 15 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. FR - Francie Klíč. slova rna ; replication ; promoter ; viruses ; binding ; zika ; G-quadruplex Obor OECD Biochemistry and molecular biology CEP GA18-15548S GA ČR - Grantová agentura ČR EF15_003/0000477 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora BFU-R - RVO:68081707 UT WOS 000662667800002 EID SCOPUS 85104058471 DOI 10.1016/j.biochi.2021.03.017 Anotace G-quadruplexes contribute to the regulation of key molecular processes. Their utilization for antiviral therapy is an emerging field of contemporary research. Here we present comprehensive analyses of the presence and localization of putative G-quadruplex forming sequences (PQS) in all viral genomes currently available in the NCBI database (including subviral agents). The G4Hunter algorithm was applied to a pool of 11,000 accessible viral genomes representing 350 Mbp in total. PQS frequencies differ across evolutionary groups of viruses, and are enriched in repeats, replication origins, 50UTRs and 30UTRs. Importantly, PQS presence and localization is connected to viral lifecycles and corresponds to the type of viral infection rather than to nucleic acid type, while viruses routinely causing persistent infections in Metazoa hosts are enriched for PQS, viruses causing acute infections are significantly depleted for PQS. The unique localization of PQS identifies the importance of G-quadruplex-based regulation of viral replication and life cycle, providing a tool for potential therapeutic targeting. (C) 2021 The Authors. Published by Elsevier B.V. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2022 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0300908421000961?via%3Dihub
Počet záznamů: 1