Počet záznamů: 1
The Oral Microbiome in Periodontal Health
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SYSNO ASEP 0542109 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The Oral Microbiome in Periodontal Health Tvůrce(i) Lenartová, Magdaléna (MBU-M)
Těšínská, Barbora (MBU-M)
Janatová, T. (CZ)
Hřebíček, Ondřej (MBU-M)
Myšák, J. (CZ)
Janata, Jiří (MBU-M) RID, ORCID
Najmanová, Lucie (MBU-M) RIDČíslo článku 629723 Zdroj.dok. Frontiers in Cellular and Infection Microbiology. - : Frontiers Media - ISSN 2235-2988
Roč. 11, MAR 22 (2021)Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova oral microbiome ; periodontal health ; periodontitis ; core microbiome ; stomatotype ; taxonomic composition ; aging Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology CEP NV17-30753A GA MZd - Ministerstvo zdravotnictví Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000636669600001 EID SCOPUS 85103649777 DOI 10.3389/fcimb.2021.629723 Anotace The estimation of oral microbiome (OM) taxonomic composition in periodontally healthy individuals can often be biased because the clinically periodontally healthy subjects for evaluation can already experience dysbiosis. Usually, they are included just based on the absence of clinical signs of periodontitis. Additionally, the age of subjects is used to be higher to correspond well with tested groups of patients with chronic periodontitis, a disorder typically associated with aging. However, the dysbiosis of the OM precedes the clinical signs of the disease by many months or even years. The absence of periodontal pockets thus does not necessarily mean also good periodontal health and the obtained image of ´healthy OM´ can be distorted.To overcome this bias, we taxonomically characterized the OM in almost a hundred young students of dentistry with precise oral hygiene and no signs of periodontal disease. We compared the results with the OM composition of older periodontally healthy individuals and also a group of patients with severe periodontitis (aggressive periodontitis according to former classification system). The clustering analysis revealed not only two compact clearly separated clusters corresponding to each state of health, but also a group of samples forming an overlap between both well-pronounced states. Additionally, in the cluster of periodontally healthy samples, few outliers with atypical OM and two major stomatotypes could be distinguished, differing in the prevalence and relative abundance of two main bacterial genera: Streptococcus and Veillonella. We hypothesize that the two stomatotypes could represent the microbial succession from periodontal health to starting dysbiosis. The old and young periodontally healthy subjects do not cluster separately but a trend of the OM in older subjects to periodontitis is visible. Several bacterial genera were identified to be typically more abundant in older periodontally healthy subjects. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2021 Elektronická adresa https://www.frontiersin.org/articles/10.3389/fcimb.2021.629723/full
Počet záznamů: 1