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Conducting composite films based on chitosan or sodium hyaluronate. Properties and cytocompatibility with human induced pluripotent stem cells
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SYSNO ASEP 0533634 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Conducting composite films based on chitosan or sodium hyaluronate. Properties and cytocompatibility with human induced pluripotent stem cells Tvůrce(i) Jasenská, D. (CZ)
Kašpárková, V. (CZ)
Radaszkiewicz, K. A. (CZ)
Capáková, Z. (CZ)
Pacherník, J. (CZ)
Trchová, M. (CZ)
Minařík, A. (CZ)
Vajďák, J. (CZ)
Bárta, T. (CZ)
Stejskal, Jaroslav (UMCH-V) RID, ORCID, SAI
Lehocký, M. (CZ)
Truong, T. H. (CZ)
Moučka, R. (CZ)
Humpolíček, P. (CZ)Číslo článku 117244 Zdroj.dok. Carbohydrate Polymers. - : Elsevier - ISSN 0144-8617
Roč. 253, 1 February (2021)Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova polyaniline ; polysacharides ; conducting composites Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000596248700003 EID SCOPUS 85094181117 DOI 10.1016/j.carbpol.2020.117244 Anotace Novel composite films combining biocompatible polysaccharides with conducting polyaniline (PANI) were prepared via the in-situ polymerization of aniline hydrochloride in the presence of sodium hyaluronate (SH) or chitosan (CH). The composite films possess very good cytocompatibility in terms of adhesion and proliferation of two lines of human induced pluripotent stem cells (hiPSC). Moreover, the cardiomyogenesis and even formation of beating clusters were successfully induced on the films. The proportion of formed cardiomyocytes demonstrated excellent properties of composites for tissue engineering of stimuli-responsive tissues. The testing also demonstrated antibacterial activity of the films against E. coli and PANI-SH was able to reduce bacterial growth from 2 × 105 to < 1 cfu cm−2. Physicochemical characterization revealed that the presence of polysaccharides did not notably influence conductivities of the composites being ∼1 and ∼2 S cm−1 for PANI-SH and PANI-CH respectively. However, in comparison with neat PANI, it modified their topography making the films smoother with mean surface roughness of 4 (PANI-SH) and 14 nm (PANI-CH). The combination of conductivity, antibacterial activity and mainly cytocompatibility with hiPSC opens wide application potential of these polysaccharide-based composites. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2022 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S014486172031417X?via%3Dihub
Počet záznamů: 1