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Cyclin A1 in Oocytes Prevents Chromosome Segregation And Anaphase Entry
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SYSNO ASEP 0532026 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cyclin A1 in Oocytes Prevents Chromosome Segregation And Anaphase Entry Tvůrce(i) Radoňová, Lenka (UZFG-Y)
Pauerová, Tereza (UZFG-Y)
Jansová, Denisa (UZFG-Y) ORCID
Danadová, J. (CZ)
Škultéty, Michal (UZFG-Y) ORCID
Kubelka, Michal (UZFG-Y) RID, ORCID
Anger, Martin (UZFG-Y) ORCIDČíslo článku 7455 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 10, č. 1 (2020)Poč.str. 12 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova cyclins ; meiosis Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Cell biology CEP GA19-24528S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 000560030700001 EID SCOPUS 85084242815 DOI 10.1038/s41598-020-64418-1 Anotace In several species, including Xenopus, mouse and human, two members of cyclin A family were identified. Cyclin A2, which is ubiquitously expressed in dividing cells and plays role in DNA replication, entry into mitosis and spindle assembly, and cyclin A1, whose function is less clear and which is expressed in spermatocytes, leukemia cells and in postmitotic multiciliated cells. Deletion of the gene showed that cyclin A1 is essential for male meiosis, but nonessential for female meiosis. Our results revealed, that the cyclin A1 is not only dispensable in oocytes, we show here that its expression is in fact undesirable in these cells. Our data demonstrate that the APC/C and proteasome in oocytes are unable to target sufficiently cyclin A1 before anaphase, which leads into anaphase arrest and direct inhibition of separase. The cyclin A1-induced cell cycle arrest is oocyte-specific and the presence of cyclin A1 in early embryos has no effect on cell cycle progression or chromosome division. Cyclin A1 is therefore not only an important cell cycle regulator with biased expression in germline, being essential for male and damaging for female meiosis, its persistent expression during anaphase in oocytes shows fundamental differences between APC/C function in oocytes and in early embryos. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2021 Elektronická adresa https://www.nature.com/articles/s41598-020-64418-1
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