Počet záznamů: 1
Supported Lipid Bilayers on Fluorescent Nanodiamonds: A Structurally Defined and Versatile Coating for Bioapplications
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SYSNO ASEP 0498616 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Supported Lipid Bilayers on Fluorescent Nanodiamonds: A Structurally Defined and Versatile Coating for Bioapplications Tvůrce(i) Vávra, Jan (UOCHB-X)
Řehoř, Ivan (UOCHB-X) RID, ORCID
Rendler, T. (DE)
Jani, Mona (UOCHB-X)
Bednár, J. (CZ)
Baksh, M. M. (US)
Zappe, A. (DE)
Wrachtrup, J. (DE)
Cígler, Petr (UOCHB-X) RID, ORCIDČíslo článku 1803406 Zdroj.dok. Advanced Functional Materials - ISSN 1616-301X
Roč. 28, č. 45 (2018)Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova gadolinium ; nanodiamonds ; nitrogen-vacancy centers ; spin labels ; supported lipid bilayers Vědní obor RIV BO - Biofyzika Obor OECD Biophysics CEP GA16-16336S GA ČR - Grantová agentura ČR EF16_019/0000729 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000449706700025 EID SCOPUS 85053494999 DOI 10.1002/adfm.201803406 Anotace Fluorescent nanodiamonds with nitrogen-vacancy (NV) centers respond to local changes in electric and magnetic fields. These responses can be read optically as changes in fluorescence. NV centers do not suffer from photoblinking or photobleaching, making nanodiamonds a viable platform for long-term imaging of processes inside living cells. However, for any bioapplication, the surface of these particles must be modified to prevent aggregation and nonspecific protein adsorption and to effectively transduce the changes in local environment to NV center. Modular biomimetic interface has been developed on nanodiamonds with remarkable sensitivity for relaxometric readout that takes advantage of self-assembled phospholipid bilayers supported by the nanoparticle surface. This rapid and robust approach provides synthetic pathway to tunable composition, demonstrated by tuning surface charge and content of spin labels on nanodiamond. The supported phospholipid bilayer interface increases the detection sensitivity about one-order-of-magnitude. Also, a theoretical model of the system is provided, which shows excellent agreement with experimental results. Merging biocompatibility, modularity, and outstanding spin sensitivity in one nanomaterial provides a foundation for development of multifunctional nanoparticles suitable for highly sensitive monitoring of local magnetic field fluctuations and paramagnetic species under physiological conditions. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2019
Počet záznamů: 1